부산대학교 도서관

In this study , we used the electrospinning technology to prepare temperature-sensitive spinning fibers. Different forms of electrospinning films are prepared by controlling different electrospinning parameters, and through physical methods to test the characteristics of the nanofiber membranes to find out the better electrospinning preparation parameters. Poly(N-isopropylacrylamide), PNIPAAM polymer was chosen as the main material for prepare the electrospinning films. Control the parameters of electrospinning technology, including voltage, injection pump speed, distance between needle and collecting plate and injection needle size. Using these parameters to make temperature-sensitive, hydrophilic and hydrophobic materials with different fiber structures, and compared the morphology, structure and mechanical properties of the electrospinning film. This electrospinning film has the characteristics of high pores and high surface area structure and can be used as a substrate for drug release applications. In order to evaluate the application of electrospinning film for drug release, the electrospinning film swelling rate test was carried out to explore the influence of different spinning fiber structure on the shrinkage performance, including the thickness difference of the spun film, the difference between the normal and random spinning and the preparation parameters of the electrostatic spinning, and tension testing. In addition, by using organic dyes (Rhodamine B, RhB) as a drug model, the drug release properties of the prepared electrospinning films with different structures were evaluated. The results show that random electrospinning and thinner films are the most stable and have the highest swelling rate. The electrospinning parameters of 1 ml/hr, 8 kV, and 20 G was observed under the Field Emission Scanning Electron Microscope (SEM). And the swelling rate of the fiber is the most stable one. As for the amount of drug released, the electrospinning parameters of 1 ml/hr, 12 kV, and 20 G was the highest one. This study has successfully verified the excellent electrospinning film swelling rate among different electrospinning preparation parameters, and used organic dyes as a drug model for drug release verification, which can be further applied to medical engineering such as drug delivery and skin wound dressing in the future application areas.