부산대학교 도서관

Athletes have high risk for overtraining syndromes due to long-term high-intensity training and competition stress. Overtraining syndrome is harmful to health and also negatively affects training and athletic performance. Currently, diagnosis for overtraining syndromes integrates many physiological and biochemical items, which is time consuming, laborious and costly. Moreover, different players may show variable symptoms that made the diagnosis difficult. Many studies have shown that extracellular vesicles are secreted by cells to the extracellular environments and their specific contents are variable depending on the physiological changes. Therefore, the contents of extracellular vesicles may be used as clinical diagnostic indicators of cancer, inflammation-related symptoms or the severity of disease. This article introduced recent studies regarding the effects and mechanisms of extracellular vesicles on the regeneration and differentiation of skeletal muscle cells. In the future, the significantly changed contents of extracellular vesicles from athletes immediately after the maximal exercise may become the biomarkers of overtraining syndromes. Meanwhile, the information will be immediately available to coaches and athletes. Also, this idea is novel academically and has the potential to be applied in training.