부산대학교 도서관

Background: Coronary artery disease (CAD) is the leading cause of death and disabilities in industrially developed countries. Single nucleotide polymorphism (SNP) of chromosome 9 is associated with the risk of myocardial infarction and carotid atherosclerosis. However, little is known about the association between SNPs of chromosome 9 including rs1333049, rs4977574, rs10757278 and rs1800975 with the angiographic severity of coronary atherosclerosis in the Taiwanese population. Methods: 710 consecutive patients scheduled for diagnostic coronary angiography were enrolled. The significant CAD was defined as diameter stenosis ?d 50%. We used clinical vessel score (CVS, 0-3 vessels) and diffuseness score (DS, 0-11.5) to evaluate the angiographic severity of coronary atherosclerosis. The TaqMan genotyping assay was used for SNPs genotyping. Results：Among 710 enrolled patients, 162 (22.8%) were non-significant CAD, 168 (23.7%) were one-vessel disease, 156 (22.0%) were two-vessel disease, and 224 (31.5%) were three-vessel disease. The frequency of C allele of rs1333049 and T allele of rs1800975 were higher in those with significant CAD [odds ratio (OR) 1.31, 95% CI 1.02-1.68, p = 0.033 and OR 1.33, 95% CI 1.03-1.72, p = 0.028 respectively]. For the rs1333049, the OR of significant CAD for CC to GG genotype was 1.73 (95% CI 1.04-2.87, p = 0.032). For the rs1800975, the OR of significant CAD for TT to CC genotype was1.76 (95% CI 1.05-2.93, p = 0.030). Binary logistic regression analysis found only rs1333049 was still associated with the presence of significant CAD (p = 0.015). Haplotype analysis found GCG of rs4977574, rs1333049 and rs10757278 was associated with the presence of significant CAD (p = 0.037).Univariate and multivariate regression analysis found significant associations between CVS and rs1800975 (p = 0.031 and 0.037, respectively).None of 4 SNPs was associated with DS after multivariate analysis. Conclusion：The SNP rs1333049 on chromosome 9p21 and rs1800975 on chromosome 9q22 were associated with the angiographic severity of coronary atherosclerosis in the Taiwanese population.