부산대학교 도서관

Healthcare-associated bloodstream infections are associated with higher rates of morbidity and mortality compared with other infections. The study aimed to evaluate the long-term effect of implementing infection prevention and control (IPC) programs on the incidence density and microbiologic distribution of healthcare-associated bloodstream infections. A medical center in northern Taiwan had been following international guidelines for the surveillance and management of healthcare-associated infections (HAIs) since 1981. A retrospective study was conducted from January 1 2011 to December 31 2022. to include all healthcare-associated bloodstream infections. The trend in the incidence density of healthcare-associated bloodstream infection was analyzed, and a comparison was made between the microbiologic distribution of pathogens identified during 2011-2013 and 2020-2022. The active HAI surveillance and periodic feedback led to a significant reduction in the incidence density of healthcare-associated bloodstream infections in intensive care units (ICUs) from 2011 to 2022 (6.68 vs 5.34 episodes per 1000 patient-days, p ＜0.001). During 2020-2022, Gram-negative bacteria of gut origin were the most frequently identified pathogens. Compared with the microorganisms identified during 2011-2013, there was a significant decrease in Staphylococcus spp. and a significant increase in Enterococcus spp., Klebsiella pneumoniae, Enterobacter spp., and Burkholderia cepacia complex during 2020-2022. The implementation of IPC programs had a positive impact on reducing healthcare-associated bloodstream infections in ICUs, particularly those caused by skin-related organisms. Our research reinforces the importance of maintaining the IPC program to prevent healthcare-associated bloodstream infections.