부산대학교 도서관

Primary transitional cell carcinoma (TCC) of the prostate is a rare entity, and implies no preexisting or synchronous TCC of the urinary tract. From January 1992 to December 1994, four patients with this condition were newly diagnosed at this Hospital. This constitutes 2% (4/193) of all prostate cancers in the same period here. The follow-up period ranged from 6 months to 33 months. Prostatism and microscopic hematuria were the most common clinical presentations. Urine cytology, serum prostate specific antigen (PSA) level, histology including immunohistochemical staining with PSA monoclonal antibody are necessary to differentiate TCC from adenocarcinoma of the prostate. Three of these patients already had invasion to the prostatic stroma when diagnosed. Stroma invasion is a poor prognostic factor. Radical surgery or systemic chemotherapy combined with radical surgery should be the treatment of choice for the stroma invasion in cases of primary TCC of the prostate.