부산대학교 도서관

Enhanced cutaneous wound healing by positively charged crosslinked diethylaminoethyl dextran beads CLDD was studied in a standardized incisional wound model in 20 adult and 20 geriatric Macaca mulattarhesus partitioned equally over five time periods. Physiologic saline served as a control. Softtissue linear incisions were prepared between and 1 cm inferior to the scapulae. There were four incisions per rhesus each incision was 1.5 cm long with 1 cm of undisturbed tissue between incisions, and both the experimental CLDD and physiologic saline treatments were administered to each rhesus. The incision treatments were either CLDD and softtissue closure with 40 BioSyn sutures or sterile physiologic saline and closure with 40 BioSyn sutures. The hypothesis was CLDD would enhance cutaneous wound repair. Verification of the hypothesis consisted of clinical examinations and histologic and tensiometric evaluations on biopsy specimens at 10 and 15 days, whereas 5day and 2 and 4month groups were assessed clinically and biopsy specimens were assessed histologically.