학술논문
Association analysis of δ‐opioid receptor gene polymorphisms in methamphetamine dependence/psychosisPlease cite this article as follows: Kobayash H, Hata H, Ujike H, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Ozaki N, Itokawa M, Naka M, Ide S, Ikeda K, Numachi Y, Sora I. 2006. Association Analysis of δ‐Opioid Receptor Gene Polymorphisms in Methamphetamine Dependence/Psychosis. Am J Med Genet Part B 141B:482–486.
Document Type
Article
Author
Source
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; July 2006, Vol. 141 Issue: 5 p482-486, 5p
Subject
Language
ISSN
15524841; 1552485X
Abstract
The role of the δ‐opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon–intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis. © 2006 Wiley‐Liss, Inc.