학술논문
Association study between the PIK4CAgene and methamphetamine use disorder in a Japanese populationPlease cite this article as follows: Kanahara N, Miyatake R, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M, Hashimoto K. 2009. Association Study Between the PIK4CAGene and Methamphetamine Use Disorder in a Japanese Population. Am J Med Genet Part B 150B:233–238.
Document Type
Article
Author
Source
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; March 2009, Vol. 150 Issue: 2 p233-238, 6p
Subject
Language
ISSN
15524841; 1552485X
Abstract
Accumulating evidence suggests that phosphatidylinositol PI pathways have been involved in the secretion of dopamine DA and the regulation of DA transporter, which is a target of methamphetamine METH. A recent largescale geneassociation study in a Dutch population demonstrated that the PIK4CAgene was closely linked to schizophrenia Jungerius et al. 2007; Mol Psychiatry. Here, we conducted a case N 232–control N 233 study of the PIK4CAgene on Japanese METH abusers, which can manifest severe psychosis similar to schizophrenia. The genotype and allelic distributions of all four single nucleotide polymorphisms SNPs did not differ significantly between the METH abusers and the controls. The comparisons based on the classification of the psychosis as transient or prolonged and on the presence or absence of spontaneous relapse revealed no significant distribution of the four SNPs compared to the controls. Furthermore, haplotype analyses showed almost the same frequencies between the METH abusers and the controls. The present study suggests that the PIK4CAgene does not play a significant role in the vulnerability to METH use disorder in the Japanese population. © 2008 WileyLiss, Inc.