학술논문
PRKCBis associated with calcineurin inhibitor-induced renal dysfunction in heart transplant recipients
Document Type
Article
Author
Source
Pharmacogenetics and Genomics; May 2012, Vol. 22 Issue: 5 p336-343, 8p
Subject
Language
ISSN
17446872; 17446880
Abstract
Single nucleotide polymorphisms (SNPs) in the transforming growth factor-1 gene (TGFB1) have been inconsistently associated with calcineurin inhibitor (CNI)-induced renal dysfunction following cardiac transplantation. The impact of genetic variants related to the renin-angiotensin-aldosterone system (RAAS) and natriuretic peptides, which are implicated in CNI nephrotoxicity, is unknown. The primary objective of this study was to validate the association between two common variants in TGFB1(rs1800470, rs1800471) and postcardiac transplant renal function. The secondary objective was to investigate the effect of candidate genes related to the RAAS, natriuretic peptides, and other elements involved in the intracellular signaling of these pathways.