부산대학교 도서관

Background:Hypertension in pregnancy has been associated with increased risk for albuminuria in the future. However, there are limited data assessing the relationship between hypertensive diseases in pregnancy and renal function later in life. Therefore, we evaluated the relationship between hypertensive diseases in pregnancy and renal function later in life in the Genetic Epidemiology Network of Arteriopathy (GENOA) study.Methods and Results:This is a cross-sectional analysis of 961 women from the GENOA study (mean age 60 ? 9 years, 56 % African American). Participants were classified as nulliparous women (n= 81), women with a history of normotensive pregnancies (n= 741) and a history of a hypertensive pregnancy (n= 139). We compared adjusted associations among these groups with standardized measurements of renal function using generalized estimating equations. After adjusting for risk factors, women with a history of hypertensive pregnancy had lower measured glomerular filtration rate (GFR) by normalized iothalamate clearance and Cystatin C estimated GFR compared to women with a history of normotensive pregnancies (Table).Conclusions:A history of hypertensive pregnancy is associated with a risk for GFR decline (estimated and measured) in later life compared to women with a history of normotensive pregnancies. However, this findings should be interpreted cautiously and requires further study.