학술논문
The Effect of Caffeine on Peripheral Vascular Resistance in Isolated Perfused Guinea Pig Hind Limbs
Document Type
Article
Source
Journal of Cardiovascular Pharmacology; October 2003, Vol. 42 Issue: 4 p506-510, 5p
Subject
Language
ISSN
01602446; 15334023
Abstract
The role of caffeine in cardiovascular disease is controversial. Most of its pharmacologic actions are attributed to its role as an adenosine antagonist. Adenosine is one of the most important endogenous vasodilatative substances and is released under ischemic conditions, for example, in the skeletal muscle of patients with peripheral arterial occlusive disease. We aimed to investigate the influence of caffeine on peripheral vascular resistance and on the beneficial vasodilatory effect of adenosine in isolated perfused guinea pig hind limbs.