학술논문
Prevalence of Quinolone Resistance in Enterobacteriaceaefrom Sierra Leone and the Detection of qnrBPseudogenes and Modified LexA Binding Sites
Document Type
Article
Author
Source
Antimicrobial Agents and Chemotherapy; September 2016, Vol. 60 Issue: 11 p6920-6923, 4p
Subject
Language
ISSN
00664804; 10986596
Abstract
ABSTRACTA collection of 74 Enterobacteriaceaeisolates found in Bo, Sierra Leone, were tested for quinolone antibiotic susceptibility and resistance mechanisms. The majority of isolates (62%) were resistant to quinolones, and 61% harbored chromosomal gyrAand/or parCmutations. Plasmid-mediated quinolone resistance genes were ubiquitous, with qnrBand aac(6′)-Ib-crbeing the most prevalent. Mutated LexA binding sites were found in all qnrB1genes, and truncated qnrBpseudogenes were found in the majority of Citrobacterisolates.