학술논문
The Effect of Plurality and Obesity on Betamethasone Concentrations in Women at Risk for Preterm Delivery
Document Type
Article
Author
Gyamfi, Cynthia; Mele, Lisa; Wapner, Ronald J.; Spong, Catherine Y.; Peaceman, Alan; Sorokin, Yoram; Dudley, Donald J.; Johnson, Francee; Leveno, Kenneth J.; Caritis, Steve N.; Mercer, Brian M.; Thorp, John M.; O'Sullivan, Mary J.; Ramin, Susan M.; Carpenter, Marshall; Rouse, Dwight J.; Miodovnik, Menachem; Sibai, Baha
Source
Obstetrical and Gynecological Survey; January 2011, Vol. 66 Issue: 1 p1-2, 2p
Subject
Language
ISSN
00297828; 15339866
Abstract
Administration of antenatal corticosteroids to women who are at risk for preterm delivery and carry singletons decreases the incidence of respiratory distress syndrome in their prematurely born infants. However, it is unclear whether antenatal corticosteroids decrease the incidence of respiratory distress syndrome in women with multiple gestations. The effect of maternal obesity on the volume of distribution of betamethasone has not been evaluated, and some investigators are concerned that the concentration of drug available to the fetus may be different in an obese mother as compared with a nonobese mother.