학술논문
Isolation of malignant and functional Ly 1+T-cell clones from B-cell lymphomas
Document Type
Article
Source
Nature; July 1982, Vol. 298 Issue: 5870 p176-178, 3p
Subject
Language
ISSN
00280836; 14764687
Abstract
Recent work has shown that established B-cell tumours, previously thought to proliferate independently of immune regulation, may activate, and be regulated by, helper or suppressor T-cell subpopulations1–7. We now report a unique model of a murine sarcoma virus (MSV) induced B-cell lymphoma which is closely associated with a population of pre-malignant or malignant helper T cells. Proliferation of these T cells is not observed in vivo but is readily detected on in vitro cultivation. These results raise questions about immunological control and differentiation of malignant lymphomas in vivo.