부산대학교 도서관

ObjectiveTo ascertain the relationship between prelacteal feeding, early formula feeding and adverse health outcomes, especially hospitalisation during the first year of life.DesignMulticentre prospective cohort study.SettingSix hospitals across three cities in Vietnam.PatientsA total of 2030 pregnant women were recruited at 24–28 weeks of gestation and followed up at hospital discharge, 1, 3, 6 and 12 months post partum.Main outcome measuresRates of infant hospitalisation, diarrhoea and lower respiratory tract infection during the first 12 months.ResultsFor the final complete sample (n=1709, 84%), about one-quarter of the infants experienced diarrhoea (25.5%) or were admitted to hospital with at least one episode (24.8%), and almost half (47.6%) the cohort contracted lower respiratory tract infection by 12 months. The prevalence of prelacteal feeding was high (56.5%) while formula feeding was common (79.5%) before hospital discharge, both of which increased the risks of adverse health outcomes particularly hospitalisation by approximately 1.5-fold, with adjusted OR (95% CI) 1.43 (1.09 to 1.88) and 1.48 (1.07 to 2.05), respectively for these infants by 12 months, when compared with others who were exclusively breast fed.ConclusionsPrelacteal feeding and early formula feeding before hospital discharge are associated with higher risks of infection and hospital admission in Vietnamese infants. Support for exclusive breast feeding should be provided to mothers to avoid the adverse consequences of giving formula milk and prelateal foods.