학술논문
Suppression of HIV-2 Replication by HIV-1gagMutants
Document Type
Article
Author
Source
Biochemical and Biophysical Research Communications; July 1998, Vol. 248 Issue: 2 p418-421, 4p
Subject
Language
ISSN
0006291X; 10902104
Abstract
Gaggene mutants of human immunodeficiency virus type 1 (HIV-1) were analyzed for their potentials of inhibiting the replication of wild-type (wt) HIV-2, the second AIDS virus, in a single-round of viral replication. Of twenty-two HIV-1gagmutants examined, seven were found to efficiently interfere with the replication of wt HIV-2. Some mutants, which can suppress the replication of wt HIV-1, did not show this inhibitory effect. These mutants were defective at the late phase of viral replication. A mutant designated NL-C1a was demonstrated to be very effective against the replication of HIV-1 and HIV-2 in monocytic cells as well as in lymphocytic cells.