학술논문
Genetic variants for head size share genes and pathways with cancer
Document Type
Article
Author
Knol, Maria J.; Poot, Raymond A.; Evans, Tavia E.; Satizabal, Claudia L.; Mishra, Aniket; Sargurupremraj, Muralidharan; van der Auwera, Sandra; Duperron, Marie-Gabrielle; Jian, Xueqiu; Hostettler, Isabel C.; van Dam-Nolen, Dianne H.K.; Lamballais, Sander; Pawlak, Mikolaj A.; Lewis, Cora E.; Carrion-Castillo, Amaia; van Erp, Theo G.M.; Reinbold, Céline S.; Shin, Jean; Scholz, Markus; Håberg, Asta K.; Kämpe, Anders; Li, Gloria H.Y.; Avinun, Reut; Atkins, Joshua R.; Hsu, Fang-Chi; Amod, Alyssa R.; Lam, Max; Tsuchida, Ami; Teunissen, Mariël W.A.; Aygün, Nil; Patel, Yash; Liang, Dan; Beiser, Alexa S.; Beyer, Frauke; Bis, Joshua C.; Bos, Daniel; Bryan, R. Nick; Bülow, Robin; Caspers, Svenja; Catheline, Gwenaëlle; Cecil, Charlotte A.M.; Dalvie, Shareefa; Dartigues, Jean-François; DeCarli, Charles; Enlund-Cerullo, Maria; Ford, Judith M.; Franke, Barbara; Freedman, Barry I.; Friedrich, Nele; Green, Melissa J.; Haworth, Simon; Helmer, Catherine; Hoffmann, Per; Homuth, Georg; Ikram, M. Kamran; Jack, Clifford R.; Jahanshad, Neda; Jockwitz, Christiane; Kamatani, Yoichiro; Knodt, Annchen R.; Li, Shuo; Lim, Keane; Longstreth, W.T.; Macciardi, Fabio; Amouyel, Philippe; Arfanakis, Konstantinos; Aribisala, Benjamin S.; Bastin, Mark E.; Chauhan, Ganesh; Chen, Christopher; Cheng, Ching-Yu; de Jager, Philip L.; Deary, Ian J.; Fleischman, Debra A.; Gottesman, Rebecca F.; Gudnason, Vilmundur; Hilal, Saima; Hofer, Edith; Janowitz, Deborah; Jukema, J. Wouter; Liewald, David C.M.; Lopez, Lorna M.; Lopez, Oscar; Luciano, Michelle; Martinez, Oliver; Niessen, Wiro J.; Nyquist, Paul; Rotter, Jerome I.; Rundek, Tatjana; Sacco, Ralph L.; Schmidt, Helena; Tiemeier, Henning; Trompet, Stella; van der Grond, Jeroen; Völzke, Henry; Wardlaw, Joanna M.; Yanek, Lisa; Yang, Jingyun; Agartz, Ingrid; Alhusaini, Saud; Almasy, Laura; Ames, David; Amunts, Katrin; Andreassen, Ole A.; Armstrong, Nicola; Bernard, Manon; Blangero, John; Blanken, Laura M.E.; Boks, Marco P.; Boomsma, Dorret I.; Brickman, Adam M.; Brodaty, Henry; Buckner, Randy L.; Buitelaar, Jan K.; Cannon, Dara M.; Carr, Vaughan J.; Catts, Stanley V.; Chakravarty, M. Mallar; Chen, Qiang; Ching, Christopher R.K.; Corvin, Aiden; Crespo-Facorro, Benedicto; Curran, Joanne E.; Davies, Gareth E.; de Geus, Eco J.C.; de Zubicaray, Greig I.; den Braber, Anouk; Desrivières, Sylvane; Dillman, Allissa; Djurovic, Srdjan; Drevets, Wayne C.; Duggirala, Ravi; Ehrlich, Stefan; Erk, Susanne; Espeseth, Thomas; Fedko, Iryna O.; Fernández, Guillén; Fisher, Simon E.; Foroud, Tatiana M.; Ge, Tian; Giddaluru, Sudheer; Glahn, David C.; Goldman, Aaron L.; Green, Robert C.; Greven, Corina U.; Grimm, Oliver; Hansell, Narelle K.; Hartman, Catharina A.; Hashimoto, Ryota; Heinz, Andreas; Henskens, Frans; Hibar, Derrek P.; Ho, Beng-Choon; Hoekstra, Pieter J.; Holmes, Avram J.; Hoogman, Martine; Hottenga, Jouke-Jan; Hulshoff Pol, Hilleke E.; Jablensky, Assen; Jenkinson, Mark; Jia, Tianye; Jöckel, Karl-Heinz; Jönsson, Erik G.; Kim, Sungeun; Klein, Marieke; Kochunov, Peter; Kwok, John B.; Lawrie, Stephen M.; Le Hellard, Stephanie; Lemaître, Hervé; Loughland, Carmel; Marquand, Andre F.; Martin, Nicholas G.; Martinot, Jean-Luc; Matarin, Mar; Mathalon, Daniel H.; Mather, Karen A.; Mattay, Venkata S.; McDonald, Colm; McMahon, Francis J.; McMahon, Katie L.; E, Rebekah; McWhirter; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Michie, Patricia T.; Milaneschi, Yuri; Morris, Derek W.; Mowry, Bryan; Nho, Kwangsik; Nichols, Thomas E.; Nöthen, Markus N.; Olvera, Rene L.; Oosterlaan, Jaap; Ophoff, Roel A.; Pandolfo, Massimo; Pantelis, Christos; Pappa, Irene; Penninx, Brenda; Pike, G. Bruce; Rasser, Paul E.; Rentería, Miguel E.; Reppermund, Simone; Rietschel, Marcella; Risacher, Shannon L.; Romanczuk-Seiferth, Nina; Rose, Emma Jane; Sachdev, Perminder S.; Sämann, Philipp G.; Saykin, Andrew J.; Schall, Ulrich; Schofield, Peter R.; Schramm, Sara; Schumann, Gunter; Scott, Rodney; Shen, Li; Sisodiya, Sanjay M.; Soininen, Hilkka; Sprooten, Emma; Srikanth, Velandai; Steen, Vidar M.; Strike, Lachlan T.; Thalamuthu, Anbupalam; Toga, Arthur W.; Tooney, Paul; Tordesillas-Gutiérrez, Diana; Turner, Jessica A.; Valdés Hernández, Maria del C.; van der Meer, Dennis; Van der Wee, Nic J.A.; Van Haren, Neeltje E.M.; van 't Ent, Dennis; Veltman, Dick J.; Walter, Henrik; Weinberger, Daniel R.; Weiner, Michael W.; Wen, Wei; Westlye, Lars T.; Westman, Eric; Winkler, Anderson M.; Woldehawariat, Girma; Wright, Margaret J.; Wu, Jingqin; Mäkitie, Outi; Mazoyer, Bernard; Medland, Sarah E.; Miyamoto, Susumu; Moebus, Susanne; Mosley, Thomas H.; Muetzel, Ryan; Mühleisen, Thomas W.; Nagata, Manabu; Nakahara, Soichiro; Palmer, Nicholette D.; Pausova, Zdenka; Preda, Adrian; Quidé, Yann; Reay, William R.; Roshchupkin, Gennady V.; Schmidt, Reinhold; Schreiner, Pamela J.; Setoh, Kazuya; Shapland, Chin Yang; Sidney, Stephen; St Pourcain, Beate; Stein, Jason L.; Tabara, Yasuharu; Teumer, Alexander; Uhlmann, Anne; van der Lugt, Aad; Vernooij, Meike W.; Werring, David J.; Windham, B. Gwen; Witte, A. Veronica; Wittfeld, Katharina; Yang, Qiong; Yoshida, Kazumichi; Brunner, Han G.; Le Grand, Quentin; Sim, Kang; Stein, Dan J.; Bowden, Donald W.; Cairns, Murray J.; Hariri, Ahmad R.; Cheung, Ching-Lung; Andersson, Sture; Villringer, Arno; Paus, Tomas; Cichon, Sven; Calhoun, Vince D.; Crivello, Fabrice; Launer, Lenore J.; White, Tonya; Koudstaal, Peter J.; Houlden, Henry; Fornage, Myriam; Matsuda, Fumihiko; Grabe, Hans J.; Ikram, M. Arfan; Debette, Stéphanie; Thompson, Paul M.; Seshadri, Sudha; Adams, Hieab H.H.
Source
Cell Reports Medicine; May 2024, Vol. 5 Issue: 5
Subject
Language
ISSN
26663791
Abstract
The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.