학술논문
Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials
Document Type
Article
Author
Gray, Richard; Bradley, Rosie; Braybrooke, Jeremy; Liu, Zulian; Peto, Richard; Davies, Lucy; Dodwell, David; McGale, Paul; Pan, Hongchao; Taylor, Carolyn; Barlow, William; Bliss, Judith; Bruzzi, Paolo; Cameron, David; Fountzilas, George; Loibl, Sibylle; Mackey, John; Martin, Miguel; Del Mastro, Lucia; Möbus, Volker; Nekljudova, Valentina; De Placido, Sabino; Swain, Sandra; Untch, Michael; Pritchard, Kathleen I; Bergh, Jonas; Norton, Larry; Boddington, Clare; Burrett, Julie; Clarke, Mike; Davies, Christina; Duane, Fran; Evans, Vaughan; Gettins, Lucy; Godwin, Jon; Hills, Robert; James, Sam; Liu, Hui; MacKinnon, Elizabeth; Mannu, Gurdeep; McHugh, Theresa; Morris, Philip; Read, Simon; Wang, Yaochen; Wang, Zhe; Fasching, Peter; Harbeck, Nadia; Piedbois, Pascal; Gnant, Michael; Steger, Guenther; Di Leo, Angelo; Dolci, Stella; Francis, Prue; Larsimont, Denis; Nogaret, Jean Marie; Philippson, Catherine; Piccart, Martine; Linn, Sabine; Peer, Petronella; Tjan-Heijnen, Vivianne; Vliek, Sonja; Mackey, John; Slamon, Dennis; Bartlett, John; Bramwell, Vivien H; Chen, Bingshu; Chia, Stephen; Gelmon, Karen; Goss, Paul; Levine, Mark; Parulekar, Wendy; Pater, Joseph; Rakovitch, Eileen; Shepherd, Lois; Tu, Dongsheng; Whelan, Tim; Berry, Don; Broadwater, Gloria; Cirrincione, Constance; Muss, Hyman; Weiss, Raymond; Shan, Yi; Shao, Yong Fu; Wang, Xiang; Xu, Binghe; Zhao, Dong-Bing; Bartelink, Harry; Bijker, Nina; Bogaerts, Jan; Cardoso, Fatima; Cufer, Tanja; Julien, Jean-Pierre; Poortmans, Philip; Rutgers, Emiel; van de Velde, Cornelis; Carrasco, Eva; Segui, Miguel Angel; Blohmer, Jens Uwe; Costa, Serban; Gerber, Bernd; Jackisch, Christian; von Minckwitz, Gunter; Giuliano, Mario; De Laurentiis, Michele; Bamia, Christina; Koliou, Georgia-Angeliki; Mavroudis, Dimitris; A'Hern, Roger; Ellis, Paul; Kilburn, Lucy; Morden, James; Yarnold, John; Sadoon, Mohammad; Tulusan, Augustinus H; Anderson, Stewart; Bass, Gordon; Costantino, Joe; Dignam, James; Fisher, Bernard; Geyer, Charles; Mamounas, Eleftherios P; Paik, Soon; Redmond, Carol; Wickerham, D Lawrence; Venturini, Marco; Bighin, Claudia; Pastorino, Simona; Pronzato, Paolo; Sertoli, Mario Roberto; Foukakis, Theodorus; Albain, Kathy; Arriagada, Rodrigo; Bergsten Nordström, Elizabeth; Boccardo, Francesco; Brain, Etienne; Carey, Lisa; Coates, Alan; Coleman, Robert; Correa, Candace; Cuzick, Jack; Davidson, Nancy; Dowsett, Mitch; Ewertz, Marianne; Forbes, John; Gelber, Richard; Goldhirsch, Aron; Goodwin, Pamela; Hayes, Daniel; Hill, Catherine; Ingle, James; Jagsi, Reshma; Janni, Wolfgang; Mukai, Hirofumi; Ohashi, Yasuo; Pierce, Lori; Raina, Vinod; Ravdin, Peter; Rea, Daniel; Regan, Meredith; Robertson, John; Sparano, Joseph; Tutt, Andrew; Viale, Giuseppe; Wilcken, Nicholas; Wolmark, Norman; Wood, Wiliam; Zambetti, Milvia
Source
The Lancet; April 2019, Vol. 393 Issue: 10179 p1440-1452, 13p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Increasing the dose intensity of cytotoxic therapy by shortening the intervals between cycles, or by giving individual drugs sequentially at full dose rather than in lower-dose concurrent treatment schedules, might enhance efficacy.