학술논문
The impact of COVID-19 restrictions on participant enrollment in the PREPARE trial
Document Type
Article
Author
Pogorzelski, David; McKay, Paula; Weaver, Michael J.; Jaeblon, Todd; Hymes, Robert A.; Gaski, Greg E.; Fraifogl, Joanne; Ahn, James S.; Bzovsky, Sofia; Slobogean, Gerard; Sprague, Sheila; Slobogean, Gerard P.; Sprague, Sheila; Wells, Jeffrey; Bhandari, Mohit; Slobogean, Gerard P.; Bhandari, Mohit; Sprague, Sheila; Harris, Anthony D.; Mullins, C. Daniel; Thabane, Lehana; Wells, Jeffrey; Wood, Amber; Della Rocca, Gregory J.; Harris, Anthony D.; Hebden, Joan; Jeray, Kyle J.; Marchand, Lucas S.; O'Hara, Lyndsay M.; Zura, Robert; Lee, Christopher; Patterson, Joseph; Gardner, Michael J.; Blasman, Jenna; Davies, Jonah; Liang, Stephen; Taljaard, Monica; Devereaux, P.J.; Guyatt, Gordon H.; Thabane, Lehana; Heels-Ansdell, Diane; Marvel, Debra; Palmer, Jana; Wells, Jeffrey; Friedrich, Jeff; Mullins, C. Daniel; O'Hara, Nathan N.; Grissom, Ms Frances; Della Rocca, Gregory J.; Gitajn, I. Leah; Jeray, Kyle J.; Morshed, Saam; O'Toole, Robert V.; Petrisor, Bradley A.; Mossuto, Franca; Harris, Anthony D.; Joshi, Manjari G.; D'Alleyrand, Jean-Claude; Fowler, Justin; Rivera, Jessica; Talbot, Max; Sprague, Sheila; Bhandari, Mohit; Pogorzelski, David; Dodds, Shannon; Li, Silvia; Rojas, Alejandra; Del Fabbro, Gina; Szasz, Olivia Paige; Heels-Ansdell, Diane; McKay, Paula; Minea, Alexandra; Murphy, Kevin; Slobogean, Gerard P.; O'Hara, Nathan N.; Howe, Andrea; Demyanovich, Haley; Mullins, C. Daniel; Medeiros, Michelle; Polk, Genevieve; Kettering, Eric; Mahal, Nirmen; O'Toole, Robert V.; D'Alleyrand, Jean-Claude; Eglseder, Andrew; Johnson, Aaron; Langhammer, Christopher; Lebrun, Christopher; Nascone, Jason; Pensy, Raymond; Pollak, Andrew; Sciadini, Marcus; Slobogean, Gerard P.; Degani, Yasmin; Demyanovich, Haley K.; Howe, Andrea; O'Hara, Nathan N.; Phipps, Heather; Hempen, Eric; Holler, Christine; Petrisor, Brad A.; Johal, Herman; Ristevski, Bill; Williams, Dale; Denkers, Matthew; Rajaratnam, Krishan; Al-Asiri, Jamal; Gallant, Jodi; Pusztai, Kaitlyn; MacRae, Sarah; Renaud, Sara; Jeray, Kyle J.; Adams, John D.; Beckish, Michael L.; Bray, Christopher C.; Brown, Timothy R.; Cross, Andrew W.; Dew, Timothy; Faucher, Gregory K.; Gurich, Richard W.; Lazarus, David E.; Millon, S. John; Moody, M. Christian; Palmer, M. Jason; Porter, Scott E.; Schaller, Thomas M.; Sridhar, Michael S.; Sanders, John L.; Rudisill, L. Edwin; Garitty, Michael J.; Poole, Andrew S.; Sims, Michael L.; Walker, Clark M.; Carlisle, Robert; Hofer, Erin A.; Huggins, Brandon; Hunter, Michael; Marshall, William; Ray, Shea B.; Smith, Cory; Altman, Kyle M.; Pichiotino, Erin; Quirion, Julia C.; Loeffler, Markus F.; Pichiotino, Erin R.; Cole, Austin A.; Maltz, Ethan J.; Parker, Wesley; Ramsey, T. Bennett; Burnikel, Alex; Colello, Michael; Stewart, Russell; Wise, Jeremy; Anderson, Matthew; Eskew, Joshua; Judkins, Benjamin; Miller, James M.; Tanner, Stephanie L.; Snider, Rebecca G.; Townsend, Christine E.; Pham, Kayla H.; Martin, Abigail; Robertson, Emily; Bray, Emily; Sykes, J. Wilson; Yoder, Krystina; Conner, Kelsey; Abbott, Harper; Natoli, Roman M.; McKinley, Todd O.; Virkus, Walter W.; Sorkin, Anthony T.; Szatkowski, Jan P.; Mullis, Brian H.; Jang, Yohan; Lopas, Luke A.; Hill, Lauren C.; Fentz, Courteney L.; Diaz, Maricela M.; Brown, Krista; Garst, Katelyn M.; Denari, Emma W.; Osborn, Patrick; Fowler, Justin; Pierrie, Sarah; Herrera, Maria; Morshed, Saam; Miclau, Theodore; Marmor, Meir; Matityahu, Amir; McClellan, R. Trigg; Shearer, David; Toogood, Paul; Ding, Anthony; Murali, Jothi; El Naga, Ashraf; Tangtiphaiboontana, Jennifer; Belaye, Tigist; Berhaneselase, Eleni; Pokhvashchev, Dmitry; Obremskey, William T.; Jahangir, Amir Alex; Sethi, Manish; Boyce, Robert; Stinner, Daniel J.; Mitchell, Phillip; Trochez, Karen; Rodriguez, Elsa; Pritchett, Charles; Hogan, Natalie; Moreno, A. Fidel; Hagen, Jennifer E.; Patrick, Matthew; Vlasak, Richard; Krupko, Thomas; Talerico, Michael; Horodyski, Marybeth; Pazik, Marissa; Lossada-Soto, Elizabeth; Gary, Joshua L.; Warner, Stephen J.; Munz, John W.; Choo, Andrew M.; Achor, Timothy S.; Routt, Milton L. Chip; Kutzler, Michael; Boutte, Sterling; Warth, Ryan J.; Prayson, Michael; Venkatarayappa, Indresh; Horne, Brandon; Jerele, Jennifer; Clark, Linda; Boulton, Christina; Lowe, Jason; Ruth, John T.; Askam, Brad; Seach, Andrea; Cruz, Alejandro; Featherston, Breanna; Carlson, Robin; Romero, Iliana; Zarif, Isaac; Dehghan, Niloofar; McKee, Michael; Jones, Clifford B.; Sietsema, Debra L.; Williams, Alyse; Dykes, Tayler; Guerra-Farfan, Ernesto; Tomas-Hernandez, Jordi; Teixidor-Serra, Jordi; Molero-Garcia, Vicente; Selga-Marsa, Jordi; Porcel-Vazquez, Juan Antonio; Andres-Peiro, Jose Vicente; Esteban-Feliu, Ignacio; Vidal-Tarrason, Nuria; Serracanta, Jordi; Nuñez-Camarena, Jorge; Mar Villar-Casares, Maria del; Mestre-Torres, Jaume; Lalueza-Broto, Pilar; Moreira-Borim, Felipe; Garcia-Sanchez, Yaiza; Marcano-Fernández, Francesc; Martínez-Carreres, Laia; Martí-Garín, David; Serrano-Sanz, Jorge; Sánchez-Fernández, Joel; Sanz-Molero, Matsuyama; Carballo, Alejandro; Pelfort, Xavier; Acerboni-Flores, Francesc; Alavedra-Massana, Anna; Anglada-Torres, Neus; Berenguer, Alexandre; Cámara-Cabrera, Jaume; Caparros-García, Ariadna; Fillat-Gomà, Ferran; Fuentes-López, Ruben; Garcia-Rodriguez, Ramona; Gimeno-Calavia, Nuria; Martínez-Álvarez, Marta; Martínez-Grau, Patricia; Pellejero-García, Raúl; Ràfols-Perramon, Ona; Peñalver, Juan Manuel; Domènech, Mònica Salomó; Soler-Cano, Albert; Velasco-Barrera, Aldo; Yela-Verdú, Christian; Bueno-Ruiz, Mercedes; Sánchez-Palomino, Estrella; Andriola, Vito; Molina-Corbacho, Matilde; Maldonado-Sotoca, Yeray; Gasset-Teixidor, Alfons; Blasco-Moreu, Jorge; Fernández-Poch, Núria; Rodoreda-Puigdemasa, Josep; Verdaguer-Figuerola, Arnau; Cueva-Sevieri, Heber Enrique; Garcia-Gimenez, Santiago; Viskontas, Darius G.; Apostle, Kelly L.; Boyer, Dory S.; Moola, Farhad O.; Perey, Bertrand H.; Stone, Trevor B.; Lemke, H. Michael; Spicer, Ella; Payne, Kyrsten; Hymes, Robert A.; Schwartzbach, Cary C.; Schulman, Jeff E.; Malekzadeh, A. Stephen; Holzman, Michael A.; Gaski, Greg E.; Wills, Jonathan; Pilson, Holly; Carroll, Eben A.; Halvorson, Jason J.; Babcock, Sharon; Goodman, J. Brett; Holden, Martha B.; Williams, Wendy; Hill, Taylor; Brotherton, Ariel; Romeo, Nicholas M.; Vallier, Heather A.; Vergon, Anna; Higgins, Thomas F.; Haller, Justin M.; Rothberg, David L.; Marchand, Lucas S.; Olsen, Zachary M.; McGowan, Abby V.; Hill, Sophia; Dauk, Morgan K.; Bergin, Patrick F.; Russell, George V.; Graves, Matthew L.; Morellato, John; McGee, Sheketha L.; Bhanat, Eldrin L.; Yener, Ugur; Khanna, Rajinder; Nehete, Priyanka; Potter, David; VanDemark, Robert; Seabold, Kyle; Staudenmier, Nicholas; Gitajn, I. Leah; Coe, Marcus; Dwyer, Kevin; Mullin, Devin S.; Chockbengboun, Theresa A.; DePalo, Peter A.; Phelps, Kevin; Bosse, Michael; Karunakar, Madhav; Kempton, Laurence; Sims, Stephen; Hsu, Joseph; Seymour, Rachel; Churchill, Christine; Mayfield, Ada; Sweeney, Juliette; Jaeblon, Todd; Beer, Robert; Demyanovich, Haley K.; Bauer, Brent; Meredith, Sean; Talwar, Sneh; Domes, Christopher M.; Gage, Mark J.; Reilly, Rachel M.; Paniagua, Ariana; Dupree, JaNell; Weaver, Michael J.; von Keudell, Arvind G.; Sagona, Abigail E.; Mehta, Samir; Donegan, Derek; Horan, Annamarie; Dooley, Mary; Heng, Marilyn; Harris, Mitchel B.; Lhowe, David W.; Esposito, John G.; Alnasser, Ahmad; Shannon, Steven F.; Scott, Alesha N.; Clinch, Bobbi; Weber, Becky; Beltran, Michael J.; Archdeacon, Michael T.; Sagi, Henry Claude; Wyrick, John D.; Le, Theodore Toan; Laughlin, Richard T.; Thomson, Cameron G.; Hasselfeld, Kimberly; Lin, Carol A.; Vrahas, Mark S.; Moon, Charles N.; Little, Milton T.; Marecek, Geoffrey S.; Dubuclet, Denice M.; Scolaro, John A.; Learned, James R.; Lim, Philip K.; Demas, Susan; Amirhekmat, Arya; Cruz, Yan Marco Dela
Source
Contemporary Clinical Trials Communications; October 2022, Vol. 29 Issue: 1
Subject
Language
ISSN
24518654
Abstract
At the initiation of the COVID-19 pandemic, restrictions forced researchers to decide whether to continue their ongoing clinical trials. The PREPARE (Pragmatic Randomized Trial Evaluating Pre-Operative Alcohol Skin Solutions in Fractured Extremities) trial is a pragmatic cluster-randomized crossover trial in patients with open and closed fractures. PREPARE was enrolling over 200 participants per month at the initiation of the pandemic. We aim to describe how the COVID-19 research restrictions affected participant enrollment.