학술논문
Prediction of PPAR-α ligand-mediated physiological changes using gene expression profiles
Document Type
Article
Author
Source
Journal of Lipid Research; March 2004, Vol. 45 Issue: 3 p592-601, 10p
Subject
Language
ISSN
00222275; 15397262
Abstract
Peroxisome proliferator-activated receptor (PPAR)-α controls the transcription of a variety of genes involved in lipid metabolism and is the target receptor for the hypolipidemic drug class of fibrates. In the present study, the molecular and physiological effects of seven different PPAR-activating drugs have been examined in a rodent model of dyslipidemia. The drugs examined were selected to display varying potencies and efficacies toward PPAR-α. To help elucidate the link between the gene regulation elicited by PPAR-α ligands and the concomitant physiological changes, we have used cDNA microarray analysis to identify smaller gene sets that are predictive of the function of these ligands.