학술논문
Design, synthesis and preliminary biological evaluation of a focused combinatorial library of stereodiverse carbohydrate-scaffold-based peptidomimetics
Document Type
Article
Author
Source
Bioorganic & Medicinal Chemistry; February 2001, Vol. 9 Issue: 2 p511-523, 13p
Subject
Language
ISSN
09680896; 14643391
Abstract
A focused combinatorial library of 126 mimetics of the RGD sequence based on sugar scaffolds have been rationally constructed using molecular modeling, with a particular emphasis on the stereodiversityof the library. A liquid phase, mix and divide synthesis was used, active compounds being identified by using orthogonal libraries and recursive deconvolution strategies.