부산대학교 도서관

INTRODUCTION:Compared to pediatric population, treatment outcomes of adult B- lymphoblastic leukemia (B-ALL) remains dismal with long term disease free survival (DFS) of 40-45%. A high-risk subgroup of ALL called Ph-like ALL was recently identified based on similar genomic expression profile to Ph+ ALL, but with lack of Philadelphia (Ph+) chromosome. These patients have a variety of gene mutations/rearrangement including CRLF2, JAK2, KRAS, NRAS, PTPN11, ABL1, ABL2, CSF1R, PDGFRB, and they were shown to have high risk of disease relapse with poor survival outcomes. Although rare, certain Ph-like ALL patients have concurrent Ph+ chromosome and its clinical significance in Ph-like patients is largely unknown. The goal of our study was to characterize the prognostic impact of concurrent Ph+ chromosome on survival outcomes in Ph-like B-ALL patients.