부산대학교 도서관

Respiratory infection caused by P. aeruginosais one of the most critical health burdens worldwide. People affected by P. aeruginosainfection include patients with a weakened immune system, such as those with cystic fibrosis (CF) genetic disease or non-CF bronchiectasis. Disease outcomes range from fatal pneumonia to chronic life-threatening infection and inflammation leading to the progressive deterioration of pulmonary function. The development of these respiratory infections is mediated by multiple causes. However, the genetic factors underlying infection susceptibility are poorly known and difficult to predict. Our study employed novel approaches and improved mouse disease models to identify genetic modifiers that affect the severity of P. aeruginosalung infection. We identified candidate genes to enhance our understanding of P. aeruginosainfection in humans and provide a proof of concept that could be exploited for other human pathologies mediated by bacterial infection.