학술논문
Modified Phenazines from an Indonesian Streptomycessp.†
Document Type
Article
Author
Source
Journal of Natural Products; March 2010, Vol. 73 Issue: 3 p472-475, 4p
Subject
Language
ISSN
01633864; 15206025
Abstract
Fractionation of the extract from the Indonesian Streptomycessp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives.