학술논문
Differential impact of IDH1/2mutational subclasses on outcome in adult AML: Results from a large multicenter study
Document Type
Article
Author
Middeke, Jan M.; Metzeler, Klaus H.; Röllig, Christoph; Kramer, Michael; Eckardt, Jan–Niklas; Stasik, Sebastian; Greif, Philipp A.; Spiekermann, Karsten; Rothenberg-Thurley, Maja; Krug, Utz; Braess, Jan; Krämer, Alwin; Hochhaus, Andreas; Brümmendorf, Tim H.; Naumann, Ralph; Steffen, Björn; Einsele, Hermann; Schaich, Markus; Burchert, Andreas; Neubauer, Andreas; Görlich, Dennis; Sauerland, Cristina; Schäfer-Eckart, Kerstin; Schliemann, Christoph; Krause, Stefan W.; Hänel, Mathias; Frickhofen, Norbert; Noppeney, Richard; Kaiser, Ulrich; Kaufmann, Martin; Kunadt, Desiree; Wörmann, Bernhard; Sockel, Katja; Bonin, Malte von; Herold, Tobias; Müller-Tidow, Carsten; Platzbecker, Uwe; Berdel, Wolfgang E.; Serve, Hubert; Baldus, Claudia D.; Ehninger, Gerhard; Schetelig, Johannes; Hiddemann, Wolfgang; Bornhäuser, Martin; Stölzel, Friedrich; Thiede, Christian
Source
Blood Advances; 20210101, Issue: Preprints
Subject
Language
ISSN
24739529; 24739537
Abstract
Mutations of the isocitrate dehydrogenase-1 (IDH1) and IDH2genes are amongst the most frequent alterations in acute myeloid leukemia (AML) and can be found in ~20% of patients at diagnosis. Among4930 patients (median age 56 years, interquartile range 45-66) with newly diagnosed, intensively treated AML,wehave identified IDH1mutations (mIDH1) in 423 (8.6%) and IDH2mutations (mIDH2)in575 (11.7%) patients.Overall, there were no differences in response rates or survival for patients with mIDH1or mIDH2compared to patients without mutated IDH1/2. However, distinct clinical and co-mutational phenotypes of the most common subtypes of IDH1/2 mutations could be associated with differences in outcome.