학술논문
PCSK9genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Document Type
Article
Author
Schmidt, Amand F; Swerdlow, Daniel I; Holmes, Michael V; Patel, Riyaz S; Fairhurst-Hunter, Zammy; Lyall, Donald M; Hartwig, Fernando Pires; Horta, Bernardo Lessa; Hyppönen, Elina; Power, Christine; Moldovan, Max; van Iperen, Erik; Hovingh, G Kees; Demuth, Ilja; Norman, Kristina; Steinhagen-Thiessen, Elisabeth; Demuth, Juri; Bertram, Lars; Liu, Tian; Coassin, Stefan; Willeit, Johann; Kiechl, Stefan; Willeit, Karin; Mason, Dan; Wright, John; Morris, Richard; Wanamethee, Goya; Whincup, Peter; Ben-Shlomo, Yoav; McLachlan, Stela; Price, Jackie F; Kivimaki, Mika; Welch, Catherine; Sanchez-Galvez, Adelaida; Marques-Vidal, Pedro; Nicolaides, Andrew; Panayiotou, Andrie G; Onland-Moret, N Charlotte; van der Schouw, Yvonne T; Matullo, Giuseppe; Fiorito, Giovanni; Guarrera, Simonetta; Sacerdote, Carlotta; Wareham, Nicholas J; Langenberg, Claudia; Scott, Robert; Luan, Jian'an; Bobak, Martin; Malyutina, Sofia; Pająk, Andrzej; Kubinova, Ruzena; Tamosiunas, Abdonas; Pikhart, Hynek; Husemoen, Lise Lotte Nystrup; Grarup, Niels; Pedersen, Oluf; Hansen, Torben; Linneberg, Allan; Simonsen, Kenneth Starup; Cooper, Jackie; Humphries, Steve E; Brilliant, Murray; Kitchner, Terrie; Hakonarson, Hakon; Carrell, David S; McCarty, Catherine A; Kirchner, H Lester; Larson, Eric B; Crosslin, David R; de Andrade, Mariza; Roden, Dan M; Denny, Joshua C; Carty, Cara; Hancock, Stephen; Attia, John; Holliday, Elizabeth; O'Donnell, Martin; Yusuf, Salim; Chong, Michael; Pare, Guillaume; van der Harst, Pim; Said, M Abdullah; Eppinga, Ruben N; Verweij, Niek; Snieder, Harold; Christen, Tim; Mook-Kanamori, Dennis O; Gustafsson, Stefan; Lind, Lars; Ingelsson, Erik; Pazoki, Raha; Franco, Oscar; Hofman, Albert; Uitterlinden, Andre; Dehghan, Abbas; Teumer, Alexander; Baumeister, Sebastian; Dörr, Marcus; Lerch, Markus M; Völker, Uwe; Völzke, Henry; Ward, Joey; Pell, Jill P; Smith, Daniel J; Meade, Tom; Maitland-van der Zee, Anke H; Baranova, Ekaterina V; Young, Robin; Ford, Ian; Campbell, Archie; Padmanabhan, Sandosh; Bots, Michiel L; Grobbee, Diederick E; Froguel, Philippe; Thuillier, Dorothée; Balkau, Beverley; Bonnefond, Amélie; Cariou, Bertrand; Smart, Melissa; Bao, Yanchun; Kumari, Meena; Mahajan, Anubha; Ridker, Paul M; Chasman, Daniel I; Reiner, Alex P; Lange, Leslie A; Ritchie, Marylyn D; Asselbergs, Folkert W; Casas, Juan-Pablo; Keating, Brendan J; Preiss, David; Hingorani, Aroon D; Sattar, Naveed
Source
The Lancet Diabetes & Endocrinology; February 2017, Vol. 5 Issue: 2 p97-105, 9p
Subject
Language
ISSN
22138587; 22138595
Abstract
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.