학술논문
Rifampin Prophylaxis for Contacts of Haemophilus influenzae Type b Disease
Document Type
Article
Author
Source
JAMA: Journal of the American Medical Association; March 1981, Vol. 245 Issue: 10 p1043-1045, 3p
Subject
Language
ISSN
00987484; 15383598
Abstract
Rifampin prophylaxis (20 mg/kg once daily for four days) was used in close contacts of children with Haemophilus influenzae type b (HIB) disease. Two hours after a dose, the concentration of rifampin in serum and saliva exceeded the minimum bactericidal concentrations of organisms obtained from four of the carriers. In both a randomized prospective and an open study, nasopharyngeal carriage was eradicated in 37 (95%) of 39 contacts. No cases of serious H influenzae disease occurred in four to six months of follow-up. At the dose and treatment schedule used, rifampin was safe and effective for eradication of HIB carriage.(JAMA 1981;245:1043-1045)