학술논문
The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis
Document Type
Article
Author
Source
Cancer Biology and Therapy; May 2009, Vol. 8 Issue: 10 p923-929, 7p
Subject
Language
ISSN
15384047; 15558576
Abstract
There is an acute need for the development of effective therapies for mucositis, a debilitating side effect of cancer chemotherapy. Iberogast® is a herbal extract reported to possess anti- inflammatory properties. We investigated Iberogast® for its potential to reduce the severity of 5-Fluorouracil (FU)-induced mucositis in rats. Rats were allocated to 3 treatment groups (n=8) and gavaged daily with a 10% solution of Iberogast® or water from day-0 to day-8. Rats were injected intraperitoneally with 5-FU (150mg/kg) or saline on day-6, and killed after 72hrs. In vivo and in vitro sucrase activity was assessed by 13C-sucrose breath test (SBT) and sucrase assay respectively. Intestinal disease severity was determined by histological assessment of villus height and crypt depth. Significant increases in villus height (277±9µm) and crypt depth (67±3µm) were observed in 5-FU+Iberogast®-treated rats compared with 5- FU+Water (224±13µm and 48±2µm respectively; p