학술논문
Allelic Context of EGFRC797X–Mutant Lung Cancer Defines Four Subtypes With Heterogeneous Genomic Landscape and Distinct Clinical Outcomes
Document Type
Article
Author
Lu, Chang; Wei, Xue-Wu; Wang, Zhen; Zhou, Zhen; Liu, Yu-Tao; Zheng, Di; He, Yong; Xie, Zhan-Hong; Li, Yong; Zhang, Yan; Zhang, Yi-Chen; Huang, Zi-Jian; Mei, Shi-Qi; Liu, Jia-Qi; Guan, Xu-Hui; Deng, Yu; Chen, Zhi-Hong; Tu, Hai-Yan; Xu, Chong-Rui; Chen, Hua-Jun; Zhong, Wen-Zhao; Yang, Jin-Ji; Zhang, Xu-Chao; Mok, Tony S.K.; Wu, Yi-Long; Zhou, Qing
Source
Journal of Thoracic Oncology; 20230101, Issue: Preprints
Subject
Language
ISSN
15560864; 15561380
Abstract
EGFRC797X (C797S or C797G) mutation is the most frequent on-target mechanism of resistance to osimertinib. The hypothesis that the allelic context of C797X/T790M has implications for treatment is on the basis of sporadic reports and needs validation with larger cohorts.