학술논문
Efficacy of oral versus long-acting antipsychotic treatment in patients with early-phase schizophrenia in Europe and Israel: a large-scale, open-label, randomised trial (EULAST)
Document Type
Article
Author
Winter-van Rossum, Inge; Weiser, Mark; Galderisi, Silvana; Leucht, Stefan; Bitter, Istvan; Glenthøj, Birte; Hasan, Alkomiet; Luykx, Jurjen; Kupchik, Marina; Psota, Georg; Rocca, Paola; Stefanis, Nikos; Teitelbaum, Alexander; Bar Haim, Mor; Leucht, Claudia; Kemmler, Georg; Schurr, Timo; Kahn, René Sylvain; Fleischhacker, Walter Wolfgang; Davidson, Michael; Winter-van Rossum, Inge; Weiser, Mark; Luykx, Jurjen; Hasan, Alkomiet; Mosescu, Monica; Galderisi, Silvana; Kupchik, Marina; Stefanis, Nikos; Teitelbaum, Alexander; Rocca, Paola; Psota, Georg; Umoh, George; Bitter, Istvan; Hranov, Lucho; Hofer, Alex; Cordes, Joachim; Nilforooshan, Ramin; Bobes, Julio; Reitan, Solveig Klebo; Morrens, Manuel; Nirestean, Aurel; Geddes, John; Crespo Faccorro, Benedicto; Olajossy, Marcin; Rossi, Alessandro; Johnsen, Erik; László, Csekey; Ciobanu, Adela; Haddad, Peter; Oife, Igor; Bernardo, Miquel; Stan, Rodicutza; Jarema, Marek; Rujescu, Dan; Ustohal, Libor; Mayfield, Neil; Dazzan, Paola; Valevski, Avi; Libiger, Jan; Köhler, Richard; Mohr, Pavel; Pappa, Sofia; Drosos, Petros; Barnes, Thomas; DeClercq, Esther; Wagner, Elias; Bucci, Paola; Mucci, Armida; Rabinowitz, Yaacov; Adamopoulous, Adam; Draiman, Benjamin; Montemagni, Cristiana; Greslechner, Manfred; Herlihy, Hannah; Bolyos, Csilla; Schmidt-Kraepelin, Christian; TRUE, Jessica; Alvarez Garcia, Leticia; Walla, Berit; Sabbe, Bernhard; Emese, Lucaks; Mather, Sarah; Skoczen, Nikodem; Parnanzone, Serena; Bjarke, Jill; Karácsonyi, Krisztina; Lankshear, Steve; Garriga, Marina; Wichniak, Adam; Baumbach, Heidi; Schurr, Timo; Willebrands, Leonie; Nasib, Lyliana; Okhuijsen-Pfeifer, Cynthia; Huijsman, Elianne; Davidson, Michael; Kahn, René S; Fleischhacker, W Wolfgang
Source
The Lancet Psychiatry; March 2023, Vol. 10 Issue: 3 p197-208, 12p
Subject
Language
ISSN
22150366
Abstract
Schizophrenia is a severe psychiatric disorder with periods of remission and relapse. As discontinuation of antipsychotic medication is the most important reason for relapse, long-term maintenance treatment is key. Whether intramuscular long-acting (depot) antipsychotics are more efficacious than oral medication in preventing medication discontinuation is still unresolved. We aimed to compare time to all-cause discontinuation in patients randomly allocated to long-acting injectable (LAI) versus oral medication.