학술논문
FGL1 as a modulator of plasma D‐dimer levels: Exome‐wide marker analysis of plasma tPA, PAI‐1, and D‐dimer
Document Type
Article
Author
Thibord, Florian; Song, Ci; Pattee, Jack; Rodriguez, Benjamin A.T.; Chen, Ming‐Huei; O’Donnell, Christopher J.; Kleber, Marcus E.; Delgado, Graciela E.; Guo, Xiuqing; Yao, Jie; Taylor, Kent D.; Ozel, Ayse Bilge; Brody, Jennifer A.; McKnight, Barbara; Gyorgy, Beata; Simonsick, Eleanor; Leonard, Hampton L.; Carrasquilla, Germán D.; Guindo‐Martinez, Marta; Silveira, Angela; Temprano‐Sagrera, Gerard; Yanek, Lisa R.; Becker, Diane M.; Mathias, Rasika A.; Becker, Lewis C.; Raffield, Laura M.; Kilpeläinen, Tuomas O.; Grarup, Niels; Pedersen, Oluf; Hansen, Torben; Linneberg, Allan; Hamsten, Anders; Watkins, Hugh; Sabater‐Lleal, Maria; Nalls, Mike A.; Trégouët, David‐Alexandre; Morange, Pierre‐Emmanuel; Psaty, Bruce M.; Tracy, Russel P.; Smith, Nicholas L.; Desch, Karl C.; Cushman, Mary; Rotter, Jerome I.; de Vries, Paul S.; Pankratz, Nathan D.; Folsom, Aaron R.; Morrison, Alanna C.; März, Winfried; Tang, Weihong; Johnson, Andrew D.
Source
Journal of Thrombosis and Haemostasis; August 2021, Vol. 19 Issue: 8 p2019-2028, 10p
Subject
Language
ISSN
15387933; 15387836
Abstract
Use of targeted exome‐arrays with common, rare variants and functionally enriched variation has led to discovery of new genes contributing to population variation in risk factors. Plasminogen activator‐inhibitor 1 (PAI‐1), tissue plasminogen activator (tPA), and the plasma product D‐dimer are important components of the fibrinolytic system. There have been few large‐scale genome‐wide or exome‐wide studies of PAI‐1, tPA, and D‐dimer.