학술논문
Nonsense Mutations in BAG3are Associated With Early-Onset Dilated Cardiomyopathy in French Canadians
Document Type
Article
Author
Source
Canadian Journal of Cardiology; December 2014, Vol. 30 Issue: 12 p1655-1661, 7p
Subject
Language
ISSN
0828282X
Abstract
Dilated cardiomyopathy (DCM) is a major cause of heart failure that may require heart transplantation. Approximately one third of DCM cases are familial. Next-generation DNA sequencing of large panels of candidate genes (ie, targeted sequencing) or of the whole exome can rapidly and economically identify pathogenic mutations in familial DCM.