학술논문
Clinical phenotypes and prognostic features of embryonal tumours with multi-layered rosettes: a Rare Brain Tumor Registry study
Document Type
Article
Author
Khan, Sara; Solano-Paez, Palma; Suwal, Tannu; Lu, Mei; Al-Karmi, Salma; Ho, Ben; Mumal, Iqra; Shago, Mary; Hoffman, Lindsey M; Dodgshun, Andrew; Nobusawa, Sumihito; Tabori, Uri; Bartels, Ute; Ziegler, David S; Hansford, Jordan R; Ramaswamy, Vijay; Hawkins, Cynthia; Dufour, Christelle; André, Nicolas; Bouffet, Eric; Huang, Annie; Gonzalez CV, Almeida; Stephens, Derek; Leary, Sarah; Marrano, Paula; Fonseca, Adriana; Thacker, Nirav; Li, Bryan K.; Lindsay, Holly B.; Lassaletta, Alvaro; Bendel, Anne E.; Moertel, Christopher; Morales La Madrid, Andres; Santa-Maria, Vicente; Lavarino, Cinzia; Rivas, Eloy; Perreault, Sebastian; Ellezam, Benjamin; Weil, Alexander G; Jabado, Nada; Oviedo, Angelica; Yalon-Oren, Michal; Amariglio, Laura; Toledano, Helen; Dvir, Rina; Loukides, James; Van Meter, Timothy E.; Nakamura, Hideo; Wong, Tai-Tong; Wu, Kuo-Sheng; Cheng, Chien-Jui; Ra, Young-Shin; La Spina, Milena; Massimi, Luca; Buccoliero, Anna Maria; Reddy, Alyssa; Li, Rong; Gillespie, G. Yancey; Adamek, Dariusz; Fangusaro, Jason; Scharnhorst, David; Torkildson, Joseph; Johnston, Donna; Michaud, Jean; LafayCousin, Lucie; Chan, Jennifer; Van Landeghem, Frank; Wilson, Beverly; Camelo-Piragua, Sandra; Kabbara, Nabil; Boutarbouch, Mahjouba; Hanson, Derek; Jacobsen, Chad; Wright, Karen; Vibhakar, Rajeev; Levy, Jean M.; Wang, Yin; Catchpoole, Daniel; Gerber, Nicholas; Grotzer, Michael A.; Shen, Violet; Plant, Ashley; Dunham, Christopher; Joao Gil da Costa, Maria; Ramanujachar, Ramya; Raabe, Eric; Rubens, Jeffery; Phillips, Joanna; Gupta, Nalin; Demir, Haci Ahmet; Dahl, Christine; Jorgensen, Mette; Hwang, Eugene I.; Packer, Roger J; Smith, Amy; Tan, Enrica; Low, Sharon; Lu, Jian-Qiang; Ng, Ho- Keung; Kresak, Jesse L.; Gururangan, Sridharan; Pomeroy, Scott L.; Sirachainan, Nongnuch; Hongeng, Suradej; Magimairajan, Vanan; Sinha, Roona; Mushtaq, Naureen; Antony, Reuben; Sato, Mariko; Samuel, David; Zapotocky, Michal; Afzal, Samina; Walter, Andrew; Tihan, Tarik; Tsang, Derek S.; Gajjar, Amar; Wood, Paul; Cain, Jason E.; Downie, Peter A.; Gottardo, Nicolas; Branson, Helen; Laughlin, Suzanne; Ertl-Wagner, Birgit; Kulkarni, Abhaya V.; Taylor, Michael D.; Drake, James; Ibrahim, George M.; Dirks, Peter B.; Rutka, James T.; Somers, Gino R.; Hazrati, Lili-Naz; Bourdeaut, Franck; Padovani, Laetitia; Grundy, Richard G.; Mazewski, Claire M.; Fouladi, Maryam
Source
The Lancet Child & Adolescent Health; November 2021, Vol. 5 Issue: 11 p800-813, 14p
Subject
Language
ISSN
23524642; 23524650
Abstract
Embryonal tumours with multi-layered rosettes (ETMRs) are a newly recognised, rare paediatric brain tumour with alterations of the C19MCmicroRNA locus. Due to varied diagnostic practices and scarce clinical data, disease features and determinants of outcomes for these tumours are poorly defined. We did an integrated clinicopathological and molecular analysis of primary ETMRs to define clinical phenotypes, and to identify prognostic factors of survival and key treatment modalities for this orphan disease.