학술논문
In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosisand Nocardia brasiliensis
Document Type
Article
Author
Source
Antimicrobial Agents and Chemotherapy; September 2006, Vol. 50 Issue: 9 p3170-3172, 3p
Subject
Language
ISSN
00664804; 10986596
Abstract
ABSTRACTThe in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of Nocardia brasiliensisand Mycobacterium tuberculosiswere determined. Equal MIC50s and MIC90s (0.25 and 0.5 μg/ml, respectively) were found for susceptible and multidrug-resistant isolates of M. tuberculosis. The N. brasiliensisisolates showed an MIC90of 1 μg/ml and an MIC50of 1 μg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for M. tuberculosisbut fivefold-higher MICs for N. brasiliensis.