학술논문
In Vitro Activity of a New Isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and Other Mycobacteria
Document Type
Article
Author
Source
Antimicrobial Agents and Chemotherapy; May 2010, Vol. 54 Issue: 5 p2188-2190, 3p
Subject
Language
ISSN
00664804; 10986596
Abstract
In this work, we describe the activity of ACH-702 against clinical isolates of Mycobacterium tuberculosis and six different nontuberculous mycobacteria. The MIC50and MIC90of both susceptible and drug-resistant M. tuberculosis strains tested were 0.0625 and 0.125 µg/ml, respectively. The MIC50and MIC90values for Mycobacterium fortuitum isolates were 0.0625 µg/ml in both cases; Mycobacterium avium complex isolates showed MIC50and MIC90values of 0.25 and 4 µg/ml, respectively.