학술논문
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study
Document Type
Article
Author
Solomon, Joshua J; Danoff, Sonye K; Woodhead, Felix A; Hurwitz, Shelley; Maurer, Rie; Glaspole, Ian; Dellaripa, Paul F; Gooptu, Bibek; Vassallo, Robert; Cox, P Gerard; Flaherty, Kevin R; Adamali, Huzaifa I; Gibbons, Michael A; Troy, Lauren; Forrest, Ian A; Lasky, Joseph A; Spencer, Lisa G; Golden, Jeffrey; Scholand, Mary Beth; Chaudhuri, Nazia; Perrella, Mark A; Lynch, David A; Chambers, Daniel C; Kolb, Martin; Spino, Cathie; Raghu, Ganesh; Goldberg, Hilary J; Rosas, Ivan O; Haynes-Harp, Shana; Poli, Fernando; Vidya, Coimbatore Sree; Baron, Rebecca R.; Clouser, Timothy; Doyle, Tracy; Maeda, Anthony; Highland, Kristin B.; Albayda, Jemima F.; Collins, Sarah E.; Suresh, Karthik S.; Davis, John M.; Limper, Andrew H.; Amigues, Isabel; Eliopoulos, Kristina; Swigris, Jeffery J.; Humphries, Stephen; Huntwork, John C.; Glynn, Chris; Duncan, Steve R.; Danila, Maria I.; Glassberg, Marilyn K.; Oberstein, Elana M.; Belloli, Elizabeth A.; Briggs, Linda; Nagaraja, Vivek; Cholewa, Linda; DiFranco, Donna; Green, Edward; Liffick, Christie; Naik, Tanvi; Montas, Genevieve; Lebiedz-Odrobina, Dorota; Bissell, Reba; Wener, Mark; Lancaster, Lisa H.; Crawford, Leslie J.; Chan, Karmela; Kaner, Robert J.; Morris, Alicia; Wu, Xiaoping; Khalidi, Nader A.; Ryerson, Christopher J.; Wong, Alyson W.; Fell, Charlene D.; LeClercq, Sharon A.; Hyman, Mark; Shapera, Shane; Mittoo, Shikha; Shaffu, Shireen; Gaffney, Karl; Wilson, Andrew M.; Barratt, Shaney; Gunawardena, Harsha; Hoyles, Rachel K.; David, Joel; Kewalramani, Namrata; Maher, Toby M.; Molyneaux, Philip L.; Kokosi, Maria A.; Cates, Matthew J.; Mandizha, Mandizha; Ashish, Abdul; Chelliah, Gladstone; Parfrey, Helen; Thillai, Muhunthan; Vila, Josephine; Fletcher, Sophie V.; Beirne, Paul; Favager, Clair; Brown, Jo; Dawson, Julie K.; Ortega, Pilar Rivera; Haque, Sahena; Watson, Pippa; Khoo, Jun K.; Symons, Karen; Youssef, Peter; Mackintosh, John A.
Source
The Lancet Respiratory Medicine; January 2023, Vol. 11 Issue: 1 p87-96, 10p
Subject
Language
ISSN
22132600; 22132619
Abstract
Interstitial lung disease is a known complication of rheumatoid arthritis, with a lifetime risk of developing the disease in any individual of 7·7%. We aimed to assess the safety, tolerability, and efficacy of pirfenidone for the treatment of patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD).