학술논문

Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial
Document Type
Article
Author
Coutts, Shelagh BAnkolekar, SandeepAppireddy, RamanaArenillas, Juan FAssis, ZarinaBailey, PeterBarber, Philip ABazan, RodrigoBuck, Brian HButcher, Ken SCamden, Marie-ChristineCampbell, Bruce C VCasaubon, Leanne KCatanese, LucianaChatterjee, KausikChoi, Philip M CClarke, BrianDowlatshahi, DarFerrari, JuliaField, Thalia SGanesh, AravindGhia, DarshanGoyal, MayankGreisenegger, StefanHalse, OmidHorn, MackenzieHunter, GaryImoukhuede, OjeKelly, Peter JKennedy, JamesKenney, CarolKleinig, Timothy JKrishnan, KailashLima, FabricioMandzia, Jennifer LMarko, MarthaMartins, Sheila OMedvedev, GeorgeMenon, Bijoy KMishra, Sachin MMolina, CarlosMoussaddy, AimenMuir, Keith WParsons, Mark WPenn, Andrew M WPille, ArthurPontes-Neto, Octávio MRoffe, ChristineSerena, JoaquinSimister, RobertSingh, NishitaSpratt, NeilStrbian, DanielTham, Carol HWiggam, M IvanWilliams, David JWillmot, Mark RWu, TeddyYu, Amy Y XZachariah, GeorgeZafar, AtifZerna, CharlotteHill, Michael DSalluzzi, MarinaBlenkin, NicoleDueck, AshleyDoram, CraigZhang, QiaoKenney, CarolRyckborst, KarlaBohn, ShellyCollier, QuentinTaylor, FrancesLethebe, B. CordJambula, AnithaSage, KaylaToussaint, LanaSave, SupryiaLee, JaclynLaham, NSultan, A.A.Deepak, A.Sitaram, A.Demchuk, Andrew M.Lockey, A.Micielli, A.Wadhwa, A.Arabambi, B.Graham, B.Bogiatzi, ChrysiDoshi, DarshanChakraborty, D.Kim, DianaVasquez, DSingh, DTse, DominicHarrison, E.Smith, E.E.Teleg, E.Klourfeld, E.Klein, G.Sebastian, I.A.Evans, JHegedus, JKromm, JLin, KIgnacio, KGhavami, KimiaIsmail, M.Moores, M.Panzini, M.A.Boyko, M.Almekhlafi, M.A.Newcommon, NancyMaraj, N.Imoukhuede, O.Volny, O.Stys, PeterCouillard, PhillipeOjha, P.Eswaradass, P.Joundi, RaedSingh, R.Asuncion, R.M.Muir, R.T.Dey, S.Mansoor, S.Wasyliw, S.Nagendra, S.Hu, SherryAlthubait, S.Chen, S.Bal, S.Van Gaal, StephenPeters, StevenRay, SucharitaChaturvedi, S.Subramaniam, SureshFu, VivianVillaluna, K.Maclean, G.King-Azote, P.Ma, C.Plecash, A.Murphy, C.Gorman, J.Wilson, L.Zhou, L.Benevente, O.Teal, P.Yip, S.Mann, S.Dewar, B.Demetroff, M.Shamloul, R.Beardshaw, R.Roberts, S.Blaquiere, D.Stotts, G.Shamy, M.Bereznyakova, O.Fahed, R.Alesefir, W.Lavoie, SuzyHache, A.Collard, KMackey, A.Gosselin-Lefebvre, S.Verreault, S.Beauchamp, B.Lambourn, L.Khaw, A.Mai, L.Sposato, L.Bres Bullrich, M.Azarpazhooh, R.Fridman, S.Kapoor, A.Southwell, A.Bardi, E.Fatakdawala, I.Kamra, MLopes, K.Popel, N.Norouzi, V.Liu, A.Liddy, A.M.Ghoari, B.Hawkes, C.Enriquez, C.A.Gladstone, D.J.Manosalva Alzate, H.A.Khosravani, H.Hopyan, J.J.Sivakumar, K.Son, M.Boulos, M.I.Hamind, M.A.Swartz, R.H.Murphy, R.Reiter, S.Fitzpatrick, T.Bhandari, V.Good, J.Penn, M.Naylor, M.Frost, S.Cayley, A.Akthar, F.Williams, J.Kalman, L.Crellin, L.Wiegner, R.Singh, R.S.Stewart, T.To, W.Singh, S.Pikula, A.Jaigobin, C.Carpani, F.Silver, F.Janssen, H.Schaafsma, J.del Campo, M.Alskaini, M.Rajendram, P.Fairall, P.Granfield, B.Crawford, D.Jabs, J.White, L.Sivakumar, L.Piquette, L.Nguyen, T.Nomani, A.Wagner, A.Alrohimi, A.Butt, A.D'Souza, A.Gajurel, B.Vekhande, C.Kamble, H.Kalashyan, H.Lloret, M.Benguzzi, M.Arsalan, N.Ishaque, N.Ashayeriahmadabad, R.Samiento, R.Hosseini, S.Kazi, S.Das, S.Sugumar, T.Selchen, D.Kostyrko, P.Muccilli, A.Saposnik, A.G.Vandervelde, C.Ratnayake, K.McMillan, S.Katsanos, A.Shoamanesh, A.Sahlas, D.J.Naidoo, V.Todorov, V.Toma, H.Brar, J.Lee, J.Horton, M.Chen, S.Shand, E.Weatherby, S.Jin, A.Durafourt, B.Jalini, S.Gardner, A.Tyson, C.Junk, E.Foster, K.Bolt, K.Sylvain, N.Maley, S.Urroz, L.Peeling, L.Kelly, M.Whelan, R.Cooley, R.Teitelbaum, J.Boutayeb, A.Moore, A.Cole, E.Waxman, L.Ben-Amor, N.Sanchez, R.Khalil, S.Nehme, A.Legault, C.Tampieri, D.Ehrensperger, E.Vieira, L.Cortes, M.Angle, M.Hannouche, M.Badawy, M.Werner, K.Wieszmuellner, S.Langer, A.Gisold, A.Zach, H.Rommer, P.Macher, S.Blechinger, S.Marik, W.Series, W.Baumgartinger, M.Krebs, S.Koski, J.Eirola, S.Ivanoff, T.Erakanto, A.Kupari, L.Sibolt, G.Panula, J.Tomppo, L.Tiainen, M.Ahlstrom, M.Martinez Majander, N.Suomalainen, O.Raty, S.Levi, C.Kerr, E.Allen, J.Kaauwai, L.P.Belevski, L.Russell, M.Ormond, S.Chew, A.Loiselle, A.Royan, A.Hughes, B.Garcia Esperon, C.Pepper, E.Miteff, F.He, J.Lycett, M.Min, M.Murray, N.Pavey, N.Starling de Barros, R.Gangadharan, S.Dunkerton, S.Waller, S.Canento Sanchez, T.Wellings, T.Edmonds, G.Whittaker, K.A.Ewing, M.Lee, P.Singkang, R.McDonald, A.Dos Santos, A.Shin, C.Jackson, D.Tsoleridis, J.Fisicchia, L.Parsons, N.Shenoy, N.Smith, S.Sharobeam, A.Balabanski, A.Park, A.Williams, C.Pavlin-Premri, D.Rodrigues, E.Alemseged, F.Ng, F.Zhao, H.Beharry, J.Ng, J.L.Williamson, J.Wong, J.Z.W.Li, K.Kwan, M.K.Valente, M.Yassi, N.Cooley, R.Yogendrakumar, V.McNamara, B.Buchanan, C.McCarthy, C.Thomas, G.Stephens, K.Chung, M.Chung, M.F.Tang, M.Busch, T.Frost, T.Lee, R.Stuart, N.Pachani, N.Menon, A.Borojevic, B.Linton, C.M.Garcia, G.Callaly, E.P.Dewey, H.Liu, J.Chen, J.Wong, J.Nowak, K.To, K.Lizak, N.S.Bhalala, O.Park, P.Tan, P.Martins, R.Cody, R.Forbes, R.Chen, S.K.Ooi, S.Tu, S.Dang, Y.L.Ling, Z.Cranefield, J.Drew, R.Tan, A.Kurunawai, C.Harvey, J.Mahadevan, J.J.Cagi, L.Palanikumar, L.Chia, L.N.Goh, R.El-Masri, S.Urbi, B.Rapier, C.Berrill, H.McEvoy, H.Dunning, R.Kuriakose, S.Chad, T.Sapaen, V.Sabet, A.Shah, D.Yeow, D.Lilley, K.Ward, K.Mozhy Mahizhnan, M.Tan, M.Lynch, C.Coveney, S.Tobin, K.McCabe, J.Marnane, M.Murphy, S.Large, M.Moynihan, B.Boyle, K.Sanjuan, E.Sanchis, M.Boned, S.Pancorbo, O.Sala, V.Garcia, L.Garcia-Tornel, A.Juega, J.Pagola, J.Santana, K.Requena, M.Muchada, M.Olive, M.Lozano, P.J.Rubiera, M.Deck, M.Rodriguez, N.Gomez, B.Reyes Munoz, F.J.Gomez, A.S.Sanz, A.C.Garcia, E.C.Penacoba, G.Ramos, M.E.de Lera Alfonso, M.Feliu, APardo, L.Ramirez, P.Murillo, A.Lopez Dominguez, D.Rodriguez, J.Terceno Izaga, M.Reina, M.Viturro, S.B.Bojaryn, U.Vera Monge, V.A.Silva Blas, Y.R Siew, R.Agustin, S JSeet, C.Tianming, T.d'Emden, A.Murray, A.Welch, A.Hatherley, K.Day, N.Smith, W.MacRae, E.Mitchell, E.S.Mahmood, A.Elliot, J.Neilson, S.Biswas, V.Brown, C.Lewis, A.Ashton, A.Werring, D.Perry, R.Muhammad, R.Lee, Y.C.Black, A.Robinson, A.Williams, A.Banaras, A.Cahoy, C.Raingold, G.Marinescu, M.Atang, N.Bason, N.Francia, N.Obarey, S.Feerick, S.Joseph, J.Schulz, U.Irons, R.Benjamin, J.Quinn, L.Jhoots, M.Teal, R.Ford, G.Harston, G.Bains, H.Gbinigie, I.Mathieson, P.Irons, R.Sim, C.H.Hayter, E.Kennedy, K.Binnie, L.Priestley, N.Williams, R.Ghatala, R.Stratton, S.Blight, A.Zhang, L.Davies, A.Duffy, H.Roberts, J.Homer, J.Roberts, K.Dodd, K.Cawley, K.Martin, M.Leason, S.Cotgreave, S.Taylor, T.Nallasivan, A.Haider, S.Chakraborty, T.Webster, T.Gil, A.Martin, B.Joseph, B.Cabrera, C.Jose, D.Man, J.Aquino, J.Sebastian, S.Osterdahl, M.Kwan, M.Matthew, M.Ike, N.Bello, P.Wilding, P.Fuentes, R.Shah, R.Mashate, S.Patel, T.Nwanguma, U.Dave, V.Haber, A.Lee, A.O'Sullivan, A.Drumm, B.Dawson, A.C.Matar, T.Biswas, V.Roberts, D.Taylor, E.Rounis, E.El-Masry, A.O'Hare, C.Kalladka, D.Jamil, S.Auger, S.Raha, O.Evans, M.Vonberg, F.Kalam, S.Ali Sheikh, A.Jenkins, I.H.George, J.Kwan, J.Blagojevic, J.Saeed, M.Haji-Coll, M.Tsuda, M.Sayed, M.Winterkron, N.Thanbirajah, N.Vittay, O.Karim, R.Smail, R.C.Gauhar, S.Elmamoun, S.Malani, S.Pralhad Kelavkar, S.Hiden, J.Ferdinand, P.Sanyal, R.Varquez, R.Smith, B.Okechukwu, C.Fox, E.Collins, E.Courtney, K.Tauro, S.Patterson, C.McShane, D.Kerr, E.Roberts, G.McIImoyle, J.McGuire, K.Fearon, P.Gordon, P.Isaacs, K.Lucas, K.Smith, L.Dews, L.Bates, M.Lawrence, S.Heeley, S.Patel, V.Chin, Y.M.Sims, D.Littleton, E.Khaira, J.Nadar, K.Kieliszkowska, A.Sari, B.Domingos Belo, C.Smith, E.Manolo, E.Y.Aeron-Thomas, J.Doheny, M.Garcia Pardo, M.Recaman, M.Tibajia, M.C.Aissa, M.Mah, Y.Yu, T.Patel, V.Meenakshisundaram, S.Heller, S.Alsukhni, R.Williams, O.Farag, M.Benger, M.Engineer, A.Aissa, M.Bayhonan, S.Conway, S.Bhalla, A.Nouvakis, D.Theochari, E.Boyle, F.Teo, J.King-Robson, J.Law, K.Y.Sztriha, L.Ismail, M.McGovern, A.Day, D.Mitchell-Douglas, J.Francis, J.Iqbal, A.Punjabivaryani, P.Anonuevo Reyes, J.Anonuevo Reyes, M.Pauls, M.Buch, A.Hedstrom, A.Hutchinson, C.Kirkland, C.Newham, J.Wilkes, G.Fleming, L.Fleck, N.Franca, A.Chwal, B.Oldoni, C.Mantovani, G.Noll, G.Zanella, L.Soma, M.Secchi, T.Borelli, W.Rimoli, B.P.da Cunha Silva, G.H.Machado Galvao Mondin, L.A.Barbosa Cerantola, R.Imthon, A.K.Esaki, A.S.Camilo, M.Vincenzi, O.C.ds Cruz, R.R.Morillos, M.B.Riccioppa Rodrigues, G.G.Santos Ferreira, K.Pazini, A.M.Pena Pereira, M.A.de Albuquerque, A.L.A.Massote Fontanini, C.E.Matinez Rubio, C.F.dos Santos, D.T.Dias, F.A.Alves, F.F.A.Milani, C.Pegorer Santos, B.Winckler, F.De Souza, J.T.Bonome, L.A.M.Cury Silva, V.A.Teodoro, R.S.Modolo, G.P.Ferreira, N.C.Barbosa dos Santos, D.F.dos Santos Moreira, J.C.Cruz Guedes de Morais, A.B.Vieira, J.Mendes, G.de Queiroz, J.P.
Source
The Lancet; June 2024, Vol. 403 Issue: 10444 p2597-2605, 9p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.