학술논문
Efficacy and safety of the siRNA JNJ-73763989 and the capsid assembly modulator JNJ-56136379 (bersacapavir) with nucleos(t)ide analogues for the treatment of chronic hepatitis B virus infection (REEF-1): a multicentre, double-blind, active-controlled, randomised, phase 2b trial
Document Type
Article
Author
Yuen, Man-Fung; Asselah, Tarik; Jacobson, Ira M; Brunetto, Maurizia Rossana; Janssen, Harry L A; Takehara, Tetsuo; Hou, Jin Lin; Kakuda, Thomas N; Lambrecht, Tom; Beumont, Maria; Kalmeijer, Ronald; Guinard-Azadian, Carine; Mayer, Cristiana; Jezorwski, John; Verbinnen, Thierry; Lenz, Oliver; Shukla, Umesh; Biermer, Michael; Bourgeois, Stefan; Vanwolleghem, Thomas; Nevens, Frederik; Horsmans, Yves; Van Vlierberghe, Hans; Nastri, Ana Catharina; Lacerda, Marcus; Ramji, Alnoor; Conway, Brian; Coffin, Carla; Janssen, Harry; Fung, Scott; Shafran, Stephen; Hou, Jin Lin; Sperl, Jan; Urbanek, Petr; Plisek, Stanislav; Hejda, Vaclav; Samuel, Didier; Lacombe, Karine; Zoulim, Fabien; Guyader, Dominique; Raffi, Francois; Asselah, Tarik; Bourliere, Marc; Hilleret, Marie-Noelle; Wedemeyer, Heiner; Schulze zur Wiesch, Julian; Sprinzl, Kathrin; van Boemmel, Florian; Hilgard, Gudrun; Sabranski, Michael; Arasteh, Keikawus; Chan, Henry LY; Yuen, Man Fung; Wong, Vincent Ws; Brunetto, Maurizia Rossana; Taliani, Gloria; Andreone, Pietro; Lampertico, Pietro; Kurosaki, Masayuki; Yatsuhashi, Hiroshi; Fujiwara, Kei; Takehara, Tetsuo; Kawaoka, Tomokazu; Asahina, Yasuhiro; Enomoto, Hirayuki; Yabushita, Kazuhisa; Notsumata, Kazuo; Takaguchi, Koichi; Kawabe, Naoto; Kato, Naoya; Koji, Ogawa; Namisaki, Tadashi; Suzuki, Yoshiyuki; Yoon, Jung-Hwan; Ahn, SangHoon; Lim, Young-Suk; Paik, Seung Woon; Kiew, Kuang Kiat; Mohamed, Rosmawati; Tan, Soek Siam; Lee, Yeong Yeh; Hlebowicz, Maria; Berak, Hanna; Gasiorowski, Jacek; Halota, Waldemar; Janczewska, Ewa; Geyvandova, Natalia; Morozov, Viacheslav; Andreeva, Alla; Gusev, Denis; Bessonova, Elena; Osipenko, Marina; Romanova, Svetlana; Gankina, Natalia; Sagalova, Olga; Stepanova, Tatiana; Crespo Garcia, Javier; Diago, Moises; Inmaculada, Fernandez; Calleja, Jose Luis; Forns, Xavier; Buti, Maria; Tangkijvanich, Pisit; Tanwandee, Tawesak; Piratvisuth, Teerha; Leerapun, Apinya; Yilmaz, Gurdal; Tabak, Ömer Fehmi; Akarca, Ulus Salih; Akova, Murat; Idilman, Ramazan; Forton, Daniel; Bell, David; Agarwal, Kosh; Kennedy, Patrick; Felizarta, Franco; Sulkowski, Mark; Nahass, Ronald; Rojter, Sergio; Jacobson, Ira; Korenblat, Kevin; Gitlin, Norman
Source
The Lancet Gastroenterology & Hepatology; September 2023, Vol. 8 Issue: 9 p790-802, 13p
Subject
Language
ISSN
24681253
Abstract
JNJ-73763989 (JNJ-3989), a small interfering RNA, targets all hepatitis B virus (HBV) RNAs, reducing all HBV proteins. JNJ-56136379 (JNJ-6379; also known as bersacapavir), a capsid assembly modulator, inhibits HBV replication. We aimed to evaluate the efficacy (ie, antiviral activity) and safety of these therapeutics in combination with nucleos(t)ide analogues in patients with chronic hepatitis B.