학술논문
Associations Between ABCB1, CYP2A6, CYP2B6, CYP2D6, and CYP3A5Alleles in Relation to Efavirenz and Nevirapine Pharmacokinetics in HIV-Infected Individuals
Document Type
Article
Author
Source
Therapeutic Drug Monitoring; April 2012, Vol. 34 Issue: 2 p153-159, 7p
Subject
Language
ISSN
01634356; 15363694
Abstract
Human immunodeficiency virus (HIV)-infected individuals show large interindividual variation in response to antiretroviral therapy. Efavirenz (EFV) and nevirapine (NVP) are nonnucleoside reverse transcriptase inhibitors, which are prescribed in combination with other antiretroviral therapy in so-called highly active antiretroviral therapy. Recent studies provide evidence for the role of cytochrome P450 (CYP) genes, in particular CYP2B6, in relation to EFV and NVP pharmacokinetics. In this study, the authors investigated whether common ABCB1, CYP2A6, CYP2B6, CYP2D6, and CYP3A5alleles are associated with plasma concentrations of EFV and NVP in HIV-infected individuals.