학술논문
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1and BRCA2pathogenic variants
Document Type
Article
Author
Barnes, Daniel R.; Rookus, Matti A.; McGuffog, Lesley; Leslie, Goska; Mooij, Thea M.; Dennis, Joe; Mavaddat, Nasim; Adlard, Julian; Ahmed, Munaza; Aittomäki, Kristiina; Andrieu, Nadine; Andrulis, Irene L.; Arnold, Norbert; Arun, Banu K.; Azzollini, Jacopo; Balmaña, Judith; Barkardottir, Rosa B.; Barrowdale, Daniel; Benitez, Javier; Berthet, Pascaline; Białkowska, Katarzyna; Blanco, Amie M.; Blok, Marinus J.; Bonanni, Bernardo; Boonen, Susanne E.; Borg, Åke; Bozsik, Aniko; Bradbury, Angela R.; Brennan, Paul; Brewer, Carole; Brunet, Joan; Buys, Saundra S.; Caldés, Trinidad; Caligo, Maria A.; Campbell, Ian; Christensen, Lise Lotte; Chung, Wendy K.; Claes, Kathleen B.M.; Colas, Chrystelle; Berthet, Pascaline; Colas, Chrystelle; Collonge-Rame, Marie-Agnès; Delnatte, Capucine; Faivre, Laurence; Giraud, Sophie; Lasset, Christine; Mari, Véronique; Mebirouk, Noura; Mouret-Fourme, Emmanuelle; Schuster, Hélène; Stoppa-Lyonnet, Dominique; Adlard, Julian; Ahmed, Munaza; Antoniou, Antonis; Barrowdale, Daniel; Brennan, Paul; Brewer, Carole; Cook, Jackie; Davidson, Rosemarie; Easton, Douglas; Eeles, Ros; Evans, D. Gareth; Frost, Debra; Hanson, Helen; Izatt, Louise; Ong, Kai-ren; Side, Lucy; O’Shaughnessy-Kirwan, Aoife; Tischkowitz, Marc; Walker, Lisa; Collonge-Rame, Marie-Agnès; Cook, Jackie; Daly, Mary B.; Davidson, Rosemarie; de la Hoya, Miguel; de Putter, Robin; Delnatte, Capucine; Devilee, Peter; Diez, Orland; Ding, Yuan Chun; Domchek, Susan M.; Dorfling, Cecilia M.; Dumont, Martine; Eeles, Ros; Ejlertsen, Bent; Engel, Christoph; Evans, D. Gareth; Faivre, Laurence; Foretova, Lenka; Fostira, Florentia; Friedlander, Michael; Friedman, Eitan; Frost, Debra; Ganz, Patricia A.; Garber, Judy; Gehrig, Andrea; Gerdes, Anne-Marie; Gesta, Paul; Giraud, Sophie; Glendon, Gord; Godwin, Andrew K.; Goldgar, David E.; González-Neira, Anna; Greene, Mark H.; Gschwantler-Kaulich, Daphne; Hahnen, Eric; Hamann, Ute; Hanson, Helen; Hentschel, Julia; Hogervorst, Frans B.L.; Hooning, Maartje J.; Horvath, Judit; Hu, Chunling; Hulick, Peter J.; Imyanitov, Evgeny N.; Chenevix-Trench, Georgia; Phillips, Kelly-Anne; Spurdle, Amanda; Blok, Marinus; Devilee, Peter; Hogervorst, Frans; Hooning, Maartje; Koudijs, Marco; Mensenkamp, Arjen; Meijers-Heijboer, Hanne; Rookus, Matti; Engelen, Klaartje van; Andrieu, Nadine; Noguès, Catherine; Isaacs, Claudine; Izatt, Louise; Izquierdo, Angel; Jakubowska, Anna; James, Paul A.; Janavicius, Ramunas; John, Esther M.; Joseph, Vijai; Karlan, Beth Y.; Kast, Karin; Koudijs, Marco; Kruse, Torben A.; Kwong, Ava; Laitman, Yael; Lasset, Christine; Lazaro, Conxi; Lester, Jenny; Lesueur, Fabienne; Liljegren, Annelie; Loud, Jennifer T.; Lubiński, Jan; Mai, Phuong L.; Manoukian, Siranoush; Mari, Véronique; Mebirouk, Noura; Meijers-Heijboer, Hanne E.J.; Meindl, Alfons; Mensenkamp, Arjen R.; Miller, Austin; Montagna, Marco; Mouret-Fourme, Emmanuelle; Mukherjee, Semanti; Mulligan, Anna Marie; Nathanson, Katherine L.; Neuhausen, Susan L.; Nevanlinna, Heli; Niederacher, Dieter; Nielsen, Finn Cilius; Nikitina-Zake, Liene; Noguès, Catherine; Olah, Edith; Olopade, Olufunmilayo I.; Ong, Kai-ren; O’Shaughnessy-Kirwan, Aoife; Osorio, Ana; Ott, Claus-Eric; Papi, Laura; Park, Sue K.; Parsons, Michael T.; Pedersen, Inge Sokilde; Peissel, Bernard; Peixoto, Ana; Peterlongo, Paolo; Pfeiler, Georg; Phillips, Kelly-Anne; Prajzendanc, Karolina; Pujana, Miquel Angel; Radice, Paolo; Ramser, Juliane; Ramus, Susan J.; Rantala, Johanna; Rennert, Gad; Risch, Harvey A.; Robson, Mark; Rønlund, Karina; Salani, Ritu; Schuster, Hélène; Senter, Leigha; Shah, Payal D.; Sharma, Priyanka; Side, Lucy E.; Singer, Christian F.; Slavin, Thomas P.; Soucy, Penny; Southey, Melissa C.; Spurdle, Amanda B.; Steinemann, Doris; Steinsnyder, Zoe; Stoppa-Lyonnet, Dominique; Sutter, Christian; Tan, Yen Yen; Teixeira, Manuel R.; Teo, Soo Hwang; Thull, Darcy L.; Tischkowitz, Marc; Tognazzo, Silvia; Toland, Amanda E.; Trainer, Alison H.; Tung, Nadine; van Engelen, Klaartje; van Rensburg, Elizabeth J.; Vega, Ana; Vierstraete, Jeroen; Wagner, Gabriel; Walker, Lisa; Wang-Gohrke, Shan; Wappenschmidt, Barbara; Weitzel, Jeffrey N.; Yadav, Siddhartha; Yang, Xin; Yannoukakos, Drakoulis; Zimbalatti, Dario; Offit, Kenneth; Thomassen, Mads; Couch, Fergus J.; Schmutzler, Rita K.; Simard, Jacques; Easton, Douglas F.; Chenevix-Trench, Georgia; Antoniou, Antonis C.
Source
Genetics in Medicine; October 2020, Vol. 22 Issue: 10 p1653-1666, 14p
Subject
Language
ISSN
10983600; 15300366
Abstract
We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1and BRCA2pathogenic variant carriers.