학술논문
Antiplasmodial Activities and Cytotoxic Effects of Aqueous Extracts and Sesquiterpene Lactones from Neurolaena lobata*
Document Type
Article
Source
Planta Medica; April 1996, Vol. 62 Issue: 2 p126-129, 4p
Subject
Language
ISSN
00320943; 14390221
Abstract
Aqueous and lipophilic extracts of NEUROLAENA LOBATA (Asteraceae), obtained from Guatemala, were tested against PLASMODIUM FALCIPARUM IN VITRO. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. LOBATA, were shown to be active against P. FALCIPARUM IN VITRO. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.