학술논문
Efficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial
Document Type
Article
Author
Keij, Fleur M; Kornelisse, René F; Hartwig, Nico G; van der Sluijs-Bens, Jacqueline; van Beek, Ron H T; van Driel, Arianne; van Rooij, Linda G M; van Dalen-Vink, Ilka; Driessen, Gertjan J A; Kenter, Sandra; von Lindern, Jeannette S; Eijkemans, Marianne; Stam-Stigter, Gerda M; Qi, Hongchao; van den Berg, Maartje M; Baartmans, Martin G A; van der Meer-Kappelle, Laura H; Meijssen, Clemens B; Norbruis, Obbe F; Heidema, Jojanneke; van Rossem, Maaike C; den Butter, Paul C P; Allegaert, Karel; Reiss, Irwin K M; Tramper-Stranders, Gerdien A
Source
The Lancet Child & Adolescent Health; November 2022, Vol. 6 Issue: 11 p799-809, 11p
Subject
Language
ISSN
23524642; 23524650
Abstract
Switching from intravenous antibiotic therapy to oral antibiotic therapy among neonates is not yet practised in high-income settings due to uncertainties about exposure and safety. We aimed to assess the efficacy and safety of early intravenous-to-oral antibiotic switch therapy compared with a full course of intravenous antibiotics among neonates with probable bacterial infection.