학술논문
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines
Document Type
Article
Author
Hernandez, Nicholas; Bucciol, Giorgia; Moens, Leen; Le Pen, Jérémie; Shahrooei, Mohammad; Goudouris, Ekaterini; Shirkani, Afshin; Changi-Ashtiani, Majid; Rokni-Zadeh, Hassan; Sayar, Esra Hazar; Reisli, Ismail; Lefevre-Utile, Alain; Zijlmans, Dick; Jurado, Andrea; Pholien, Ruben; Drutman, Scott; Belkaya, Serkan; Cobat, Aurelie; Boudewijns, Robbert; Jochmans, Dirk; Neyts, Johan; Seeleuthner, Yoann; Lorenzo-Diaz, Lazaro; Enemchukwu, Chibuzo; Tietjen, Ian; Hoffmann, Hans-Heinrich; Momenilandi, Mana; Pöyhönen, Laura; Siqueira, Marilda M.; de Lima, Sheila M. Barbosa; de Souza Matos, Denise C.; Homma, Akira; Maia, Maria de Lourdes S.; da Costa Barros, Tamiris Azamor; de Oliveira, Patricia Mouta Nunes; Mesquita, Emersom Ciclini; Gijsbers, Rik; Zhang, Shen-Ying; Seligman, Stephen J.; Abel, Laurent; Hertzog, Paul; Marr, Nico; Martins, Reinaldo de Menezes; Meyts, Isabelle; Zhang, Qian; MacDonald, Margaret R.; Rice, Charles M.; Casanova, Jean-Laurent; Jouanguy, Emmanuelle; Bossuyt, Xavier
Source
The Journal of Experimental Medicine; September 2019, Vol. 216 Issue: 9 p2057-2070, 14p
Subject
Language
ISSN
00221007; 15409538
Abstract
Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR vaccines can be caused by inborn errors of type I and/or III interferon (IFN) immunity (mutations in IFNAR2, STAT1, or STAT2). Adverse reactions to the YF vaccine have remained unexplained. We report two otherwise healthy patients, a 9-yr-old boy in Iran with severe measles vaccine disease at 1 yr and a 14-yr-old girl in Brazil with viscerotropic disease caused by the YF vaccine at 12 yr. The Iranian patient is homozygous and the Brazilian patient compound heterozygous for loss-of-function IFNAR1 variations. Patient-derived fibroblasts are susceptible to viruses, including the YF and measles virus vaccine strains, in the absence or presence of exogenous type I IFN. The patients’ fibroblast phenotypes are rescued with WT IFNAR1. Autosomal recessive, complete IFNAR1 deficiency can result in life-threatening complications of vaccination with live attenuated measles and YF viruses in previously healthy individuals.