학술논문
Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries
Document Type
Article
Author
Nishath, Thamanna; Li, Xiudi; Chandramohan, Arthika; Othus, Megan; Ji, Xunda; Zou, Yihua; Sultana, Sadia; Rashid, Riffat; Sherief, Sadik Taju; Cassoux, Nathalie; Garcia Leon, Juan Luis; Díaz Coronado, Rosdali; López, Arturo Manuel Zapata; Ushakova, Tatiana L; Polyakov, Vladimir G; Roy, Soma Rani; Ahmad, Alia; Reddy, Ashwin; Sagoo, Mandeep S; Al Harby, Lamis; Kim, Jonathan W; Berry, Jesse L; Polski, Ashley; Astbury, Nick; Bascaran, Cova; Blum, Sharon; Bowman, Richard; Burton, Matthew J; Foster, Allen; Gomel, Nir; Keren-Froim, Naama; Madgar, Shiran; Zondervan, Marcia; Kaliki, Swathi; Fabian, Ido Didi; Stacey, Andrew
Source
British Journal of Ophthalmology; 2023, Vol. 107 Issue: 12 p1818-1822, 5p
Subject
Language
ISSN
00071161; 14682079
Abstract
BackgroundRates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients.MethodsA prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment.ResultsLogistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206).ConclusionCountry, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country.