부산대학교 도서관

Introduction: Obese children are at increased risk to develop severe comorbidities, including: Type 2 Diabetes Mellitus, Obstructive Sleep Apnea (OSA), Attention Deficit/Hyperactivity Disorder (ADHD) and variable psychopathology.Enuresis prevalence is increased in these specific medical conditions.This study aims to assess the association between obesity and enuresis in children and adolescents.Methods: A prospective study was performed among 344 subjects, aged 7-18 years. A questionnaire evaluated nocturnal enuresis, comorbidites and sociodemographic data. 281 subjects completed the questionnaires, 158 were normal weight, 37 overweight (85=BMI=95 percentiles, Body mass index(BMI), for age and gender) and 86 obese (BMI =95th percentile).Outcome measures: height, weight, BMI and BMI-Z-score(BMIZ), prevalence of enuresis, association between enuresis and gender, family history, voiding dysfunction, ADHD, OSA and sociodemographic variables.Results: Enuresis was present in 14(8.8%) of normal weight subjects, 6(16%) of overweight and 26(30%) of obese youth. A significant independent risk for enuresis was present in obese children (OR=6.5,95% CI(2.67-15.78)) compared to normal weight [P< 0.0001]. One unit increase in BMIZ, increases the risk for enuresis by OR of 2.14, P=0.00008,95% CI(1.46-3.12).Male gender [OR-2.84,P=0.028,95% CI(1.10-5.58)],first degree relative with current/past enuresis [OR-4.24,P=0.003, 95% CI(1.62-11.08)],voiding dysfunction symptoms [OR-3.067,P=0.041,95% CI(1.05-9.00)] and ADHD [OR-2.31,P=0.051,95% CI(0.99-5.34)] increase the subjects risk to suffer from enuresis.Conclusions: Enuresis in more prevalent among obese children. The joint risk factors support the hypothesis of a relation between the two entities. Due to this association, enuresis should be clarified during the primary workup of every obese child and adolescent.