학술논문
Characterization of Complete Lncrnas Transcriptome Reveals Expression of Lncrnas As a Prognostic Factor and Linc-SmiloAs a Potential Therapeutic Target in Multiple Myeloma
Document Type
Article
Author
Carrasco, Arantxa; Ezponda, Teresa; Meydan, Cem; Valcárcel, Luis Vitores; Ordoñez, Raquel; Kulis, Marta; Garate, Leire; Miranda, Estíbaliz; Segura, Victor; Guruceaga, Elizabeth; Vilas-Zornoza, Amaia; Alignani, Diego; Castro, Laura; Pascual, Marien; Amundarain, Ane; El Omri, Halima; Yasin, Ruba; Calasanz, Maria Jose; Planes, Francisco J; Paiva, Bruno; Mason, Christopher; San-Miguel, Jesús; Subero, Inaki Martin; Melnick, Ari M; Prosper, Felipe; Agirre, Xabier
Source
Blood; November 2019, Vol. 134 Issue: 1, Number 1 Supplement 1 p4323-4323, 1p
Subject
Language
ISSN
00064971; 15280020
Abstract
Deregulation of long non-coding RNAs (lncRNAs) is emerging as a common feature of different human tumors and their investigation may uncover novel biomarkers and oncogenic mechanisms. Previous studies have suggested that the alteration of some lncRNAs may play an important role in the pathogenesis of multiple myeloma (MM); however, the complete expression landscape of lncRNAs has not been elucidated. In the present work we characterized the lncRNAs transcriptome of MM and determined the potential involvement of lncRNAs in the pathogenesis and clinical behavior of MM.