부산대학교 도서관

In this study, we investigated the therapeutic potential of Cinnamomum camphoraleaves on allergic skin inflammation such as atopic dermatitis. We evaluated the effects of C. camphoraleaves on human adult low-calcium high-temperature keratinocytes and atopic dermatitis mice. C. camphoraleaves inhibited Macrophage-derived chemokine (an inflammatory chemokine) production in interferon-γ (10 ng/mL) stimulated Human adult low-calcium high-temperature keratinocytes in a dose dependent manner. C. camphoraleaves suppressed the phosphorylation of janus kinase signal transducer and activator of transcription 1. C. camphoraleaves also suppressed the phosphorylation of extracellular signal-regulated kinase 1/2, a central signaling molecule in the inflammation process. These results suggest that C. camphoraleaves exhibits anti-inflammatory effect via the phosphorylation of signal transducer and activator of transcription 1 and extracellular signal-regulated kinase 1/2. To study the advanced effects of C. camphoraleaves on atopic dermatitis, we induced experimental atopic dermatitis in mice by applying 2,4-dinitrochlorobenzene. The group treated with C. camphoraleaves (100 mg/kg) showed remarkable improvement of atopic dermatitis symptoms: reduced serum immunoglobulin E levels, smaller lymph nodes with reduced thickness and length, decreased ear edema, and reduced levels of inflammatory cell infiltration in the ears. Interestingly, the effects of C. camphoraleaves on atopic dermatitis symptoms were stronger than those of hydrocort cream, a positive control. Taken together, C. camphoraleaves showed alleviating effects on the inflammatory chemokine production in vitroand atopic dermatitis symptoms in vivo. These results suggest that C. camphoraleaves help in the treatment of allergic inflammation such as atopic dermatitis.