학술논문
Acute myeloid leukemias with UBTFtandem duplications are sensitive to menin inhibitors
Document Type
Article
Author
Barajas, Juan M.; Rasouli, Milad; Umeda, Masayuki; Hiltenbrand, Ryan; Abdelhamed, Sherif; Mohnani, Rebecca; Arthur, Bright; Westover, Tamara; Thomas, Melvin E.; Ashtiani, Minoo; Janke, Laura J.; Xu, Beisi; Chang, Ti-Cheng; Rosikiewicz, Wojciech; Xiong, Emily; Rolle, Chandra; Low, Jonathan; Krishan, Reethu; Song, Guangchun; Walsh, Michael P.; Ma, Jing; Rubnitz, Jeffrey E.; Iacobucci, Ilaria; Chen, Taosheng; Krippner-Heidenreich, Anja; Zwaan, Christian M.; Heidenreich, Olaf; Klco, Jeffery M.
Source
Blood; February 2024, Vol. 143 Issue: 7 p619-630, 12p
Subject
Language
ISSN
00064971; 15280020
Abstract
•UBTF tandem duplications and KMT2A/menin complex co-occupy genomic targets dysregulated in UBTF-TD acute myeloid leukemias.•UBTF-TD acute myeloid leukemias are sensitive to menin inhibition.