부산대학교 도서관

Abstract: Survival and changes in body mass of whole-body irradiated mice were determined to examine the radiorecovery and prophylactic-treatment efficacies of manganese(lIl)2(ll)(μ3-O)(μ-3,5-diisopropylsali-cylate)6(Mn3(O)(3,5-DIPS)6). To determine the radiorecovery efficacy, four groups of 25 C57BL/6 female mice were LD50/30 γ-irradiated and treated with 0, 30,40 or 50 umol Mn3(O)(3,5-DIPS)6/kg of body mass 3 h after irradiation. Survival increased from 28% in the vehicle-treated control group to 84% (p ≤0.00007), 92% (p ≤ 0.00005), or 88% (p ≤ 0.00002) in the 30, 40 or 50 mol/kg-treated groups, respectively. Postirradiation treatment with Mn3(O)(3,5-DIPS)6 enabled rapid recovery of radiation-induced loss of body mass and an overall elevated body mass when compared with the vehicle-treated control mice. To determine the combined prophylactic/therapeutic activity of this complex, four groups of 25 C57BL/6 female mice were treated with 50 umol Mn3(O)(3,5-DIPS)6/kg of body mass 3 h prior to LD100/30 γ-irradiation and then treated with 0,10,20 or 40 umol Mn3(O)(3,5-DIPS)6/kg on days 2, 4 and 6 after irradiation. Survival rates were increased to 28% (p ≤ 0.006), 12% or 16% in the 10, 20 or 40 μmol/kg postirradiation-treated mice compared with no survival in control animals. Body mass determinations revealed that mice treated with the 10 μmol/kg dose recovered from the radiation-induced loss of body mass at a more rapid pace than all other mice. These results support the hypothesis that Mn3(O)(3,5-DIPS)6 is an effective radiorecovery/radioprotective agent and that it is effective when given in a combined prophylactic/therapeutic regimen to LD100/30 whole-body-irradiated mice.