학술논문
Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3
Document Type
Article
Author
Source
Molecular Biology of the Cell; June 2015, Vol. 26 Issue: 12 p2321-2332, 12p
Subject
Language
ISSN
10591524; 19394586
Abstract
The lipogenic transcription factor SREBP1c is often aberrantly activated in cancer cells and suppresses primary cilium formation. PLA2G3 is implicated in the cilium-repressing action of SREBP1c. This involves alterations in vesicular trafficking, which is largely mediated by increased lysophospholipid levels.